US 12,487,307 B2
Distortion-free diffusion and quantitative magnetic resonance imaging with blip up-down acquisition of spin- and gradient-echoes
Berkin Bilgic, Winchester, MA (US); Zijing Zhang, Malden, MA (US); Congyu Liao, Charlestown, MA (US); JaeJin Cho, Cambridge, MA (US); and Mary Kate Manhard, Cambridge, MA (US)
Assigned to The General Hospital Corporation, Boston, MA (US)
Appl. No. 18/552,973
Filed by The General Hospital Corporation, Boston, MA (US)
PCT Filed Mar. 28, 2022, PCT No. PCT/US2022/022124
§ 371(c)(1), (2) Date Sep. 28, 2023,
PCT Pub. No. WO2022/212244, PCT Pub. Date Oct. 6, 2022.
Claims priority of provisional application 63/167,080, filed on Mar. 28, 2021.
Prior Publication US 2024/0183924 A1, Jun. 6, 2024
Int. Cl. G01R 33/563 (2006.01); G01R 33/50 (2006.01); G01R 33/56 (2006.01); G01R 33/561 (2006.01)
CPC G01R 33/56341 (2013.01) [G01R 33/50 (2013.01); G01R 33/5608 (2013.01); G01R 33/5616 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for magnetic resonance imaging, the method comprising:
(a) acquiring, with a magnetic resonance imaging (MRI) system, multi-contrast data using a multi-shot echo planar imaging (msEPI) pulse sequence comprising multiple shots, wherein a phase-encoding polarity is changed across the multiple shots of the msEPI pulse sequence and wherein in each shot data are acquired at a first echo time associated with a gradient echo, a second echo time associated with a mixed gradient-and-spin echo, and a third echo time associated with a spin echo;
(b) computing field inhomogeneity data from the multi-contrast data; and
(c) reconstructing an image from the multi-contrast data using the field (c) inhomogeneity data in order to reduce geometric distortions in the reconstructed image;
wherein the phase-encoding polarity is alternated with each subsequent shot in the msEPI pulse sequence.