US 12,486,537 B2
Methods and compositions for diagnosis and management of neurodegenerative diseases
Niketa A. Patel, Land O' Lakes, FL (US); and Jianfeng Cai, Tampa, FL (US)
Assigned to UNIVERSITY OF SOUTH FLORIDA, Tampa, FL (US); and THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, Washington, DC (US)
Filed by UNIVERSITY OF SOUTH FLORIDA, Tampa, FL (US); and THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, Washington, DC (US)
Filed on Jan. 4, 2022, as Appl. No. 17/568,617.
Application 17/568,617 is a continuation of application No. 16/001,880, filed on Jun. 6, 2018, granted, now 11,214,835.
Claims priority of provisional application 62/515,737, filed on Jun. 6, 2017.
Prior Publication US 2022/0195524 A1, Jun. 23, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C12Q 1/6883 (2018.01); A61K 31/404 (2006.01); A61K 45/06 (2006.01)
CPC C12Q 1/6883 (2013.01) [A61K 31/404 (2013.01); A61K 45/06 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01)] 22 Claims
 
1. A method comprising:
contacting a sample from a subject in need thereof having diabetes that has or is suspected of having a neurodegenerative disease with a capture molecule, wherein the capture molecule is configured to specifically bind to a biomarker and wherein the biomarker is gas5 (SNHG2);
detecting specific binding of the biomarker to the capture molecule;
quantifying an amount of the biomarker that is specifically bound to the capture molecule; and
administering a therapeutically effective amount of a compound, wherein the compound having a structure of formula 1

OG Complex Work Unit Chemistry
wherein R1 is a methyl, an isobutane, a phenyl, an indole, or a butanamine,
wherein R2 is an ethylbenzene, an ethylcyclohexane, an isopentane, a phenyl, a propanamine, or a methylcyclopropane,
wherein R3 is a methylcyclopropane, a propionic acid, an ethylbenzene, or a propanamine
wherein R4 is a butanamine, a propionic acid, or a phenyl,
wherein R5 is a methylcyclopropane, a propionic acid, or an ethylbenzene,
wherein R6 is a phenyl, a propionic acid, an isobutene, and
wherein R7 is a phenyl, a propionic acid, a butanamine, or a methyl;
or a pharmaceutical formulation thereof, to the subject in need thereof.