US 12,486,257 B2
Small molecule inhibitors of CaV3.2 activity and uses thereof
Jun Wang, Tucson, AZ (US); and Rajesh Khanna, Tucson, AZ (US)
Assigned to Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US)
Appl. No. 17/924,863
Filed by Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US)
PCT Filed May 12, 2021, PCT No. PCT/US2021/031964
§ 371(c)(1), (2) Date Nov. 11, 2022,
PCT Pub. No. WO2021/231553, PCT Pub. Date Nov. 18, 2021.
Claims priority of provisional application 63/023,672, filed on May 12, 2020.
Prior Publication US 2023/0192674 A1, Jun. 22, 2023
Int. Cl. C07D 409/14 (2006.01); A61K 45/06 (2006.01); A61P 25/02 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01)
CPC C07D 409/14 (2013.01) [A61K 45/06 (2013.01); A61P 25/02 (2018.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01)] 6 Claims
OG exemplary drawing
 
1. A compound encompassed within:

OG Complex Work Unit Chemistry
including pharmaceutically acceptable salts, solvates, and/or prodrugs thereof,
wherein X is C,
wherein R1 is selected from

OG Complex Work Unit Chemistry
wherein R2 is selected from

OG Complex Work Unit Chemistry
wherein R3 is selected from

OG Complex Work Unit Chemistry