US 12,486,219 B2
Modified tetracyclines for treatment of alcohol use disorder, pain and other disorders involving potential inflammatory processes
Susan E. Bergeson, Lubbock, TX (US); Ted W. Reid, Lubbock, TX (US); Mayank Shashtri, Lubbock, TX (US); Peter Syapin, Camarillo, CA (US); and Phat Tran, Lubbock, TX (US)
Assigned to Texas Tech University System, Lubbock, TX (US)
Appl. No. 17/251,469
Filed by Texas Tech University System, Lubbock, TX (US)
PCT Filed Jun. 13, 2019, PCT No. PCT/US2019/036928
§ 371(c)(1), (2) Date Dec. 11, 2020,
PCT Pub. No. WO2019/241490, PCT Pub. Date Dec. 19, 2019.
Claims priority of provisional application 62/684,467, filed on Jun. 13, 2018.
Claims priority of provisional application 62/684,509, filed on Jun. 13, 2018.
Prior Publication US 2021/0403416 A1, Dec. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07C 237/16 (2006.01); A61B 5/00 (2006.01); A61K 31/65 (2006.01); C07C 237/26 (2006.01); C07D 317/72 (2006.01)
CPC C07C 237/26 (2013.01) [A61B 5/4848 (2013.01); A61K 31/65 (2013.01); C07D 317/72 (2013.01); C07C 2603/46 (2017.05)] 18 Claims
 
1. A modified tetracycline molecule, pharmaceutically acceptable salts, biologically active metabolites, and tautomers thereof selected from the formulas 1 to 71, and 74 to 78 and 80 to 85:

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wherein the doxycycline, minocycline, and tigecycline structures are modified to prevent binding of the molecule to a ribosome; and
a pharmaceutically acceptable salt, buffer, excipient, filler, or carrier.