US 12,485,401 B2
Synthesizer for oligo- and polysaccharides on solid phase
Peter H. Seeberger, Kleinmachnow (DE); Jose Danglad Flores, Berlin (DE); Kim Le Mai Hoang, Grob Kreutz (DE); Alonso Pardo Vargas, Copenhagen (DK); Eric Sletten, Berlin (DE); and Mario Salwiczek, Berlin (DE)
Assigned to Max-Planck-Gesellschaft zur F6rderung der Wissenschaften e.V., Munich (DE); and Glyco Universe GmbH & Co KGaA, PotsdaM (DE)
Appl. No. 17/773,890
Filed by Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Munich (DE); and GlycoUniverse GmbH & Co KGaA, Potsdam (DE)
PCT Filed Nov. 4, 2020, PCT No. PCT/EP2020/080964
§ 371(c)(1), (2) Date May 3, 2022,
PCT Pub. No. WO2021/089623, PCT Pub. Date May 14, 2021.
Claims priority of application No. 19207015 (EP), filed on Nov. 4, 2019; and application No. 19216206 (EP), filed on Dec. 13, 2019.
Prior Publication US 2023/0026870 A1, Jan. 26, 2023
Int. Cl. B01J 19/00 (2006.01)
CPC B01J 19/0046 (2013.01) [B01J 2219/00286 (2013.01); B01J 2219/00389 (2013.01); B01J 2219/00495 (2013.01); B01J 2219/00497 (2013.01); B01J 2219/005 (2013.01); B01J 2219/00722 (2013.01); B01J 2219/00731 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A synthesizer for automated multistep synthesis on a solid support comprising:
(a) a reaction vessel,
(b) a reagent storing component comprising one or more reagent container(s),
(c) a reagent delivery system configured to establish a fluid communication between each of the one or more reagent container(s) and the reaction vessel, wherein at least two fluid communications are separate of each other,
(d) an inert gas delivery system comprising a gas container and a gas valve manifold, wherein the gas valve manifold comprises a manifold line and at least three output lines connected to the manifold line,
wherein the gas container is in fluid communication with the manifold line, the one or more reagent container(s) and the reaction vessel are in separate fluid communications with the output lines of the gas valve manifold, and wherein the at least three output lines are equipped with a means for preventing flow of reagents into the manifold line.