US 12,485,202 B2
Shape memory adhesive materials for diabetic wound healing
Xuanhe Zhao, Allston, MA (US); Hyunwoo Yuk, Cambridge, MA (US); Heejung Roh, Cambridge, MA (US); Aristidis Veves, Westwood, MA (US); and Georgios Theocharidis, Cambridge, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US); and Beth Israel Deaconess Medical Center, Boston, MA (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US); and Beth Israel Deaconess Medical Center, Boston, MA (US)
Filed on Feb. 11, 2022, as Appl. No. 17/669,442.
Claims priority of provisional application 63/148,901, filed on Feb. 12, 2021.
Prior Publication US 2024/0009346 A1, Jan. 11, 2024
Int. Cl. A61L 26/00 (2006.01); C09J 11/06 (2006.01)
CPC A61L 26/008 (2013.01) [A61L 26/0033 (2013.01); A61L 26/0038 (2013.01); A61L 26/0052 (2013.01); A61L 26/0066 (2013.01); A61L 26/0095 (2013.01); C09J 11/06 (2013.01); A61L 2400/16 (2013.01); A61L 2430/34 (2013.01)] 40 Claims
 
1. A method of healing a wound comprising:
applying a dry shape-memory adhesive material to a tissue surface surrounding the wound, the dry-shape-memory adhesive having a dry pre-stretched configuration, the tissue surface having fluid disposed thereon; and
allowing the dry pre-stretched shape-memory adhesive material to absorb at least a portion of the fluid and transform to a hydrated rubbery state to trigger (i) hydration-based adhesion to the tissue surface surrounding the wound and (ii) contraction of the shape memory adhesive material from the dry-pre-stretched configuration,
wherein the dry shape-memory adhesive material comprises one or more hydrophilic polymers, one or more amine coupling groups, and one or more cross linkers.