US 12,485,078 B2
Personal dental care product for caries treatment
Michael Hug, Zofingen (CH); and Dominikus Amadeus Lysek, Windisch (CH)
Assigned to Credentis AG, Windisch (CH)
Appl. No. 16/302,928
Filed by Credentis AG, Windisch (CH)
PCT Filed May 24, 2017, PCT No. PCT/EP2017/062589
§ 371(c)(1), (2) Date Nov. 19, 2018,
PCT Pub. No. WO2017/202940, PCT Pub. Date Nov. 30, 2017.
Claims priority of application No. 16171015 (EP), filed on May 24, 2016.
Prior Publication US 2019/0142724 A1, May 16, 2019
Int. Cl. A61K 8/64 (2006.01); A23G 3/44 (2006.01); A23G 4/14 (2006.01); A23L 33/18 (2016.01); A61K 8/02 (2006.01); A61K 8/11 (2006.01); A61K 8/19 (2006.01); A61K 8/25 (2006.01); A61K 8/34 (2006.01); A61K 8/44 (2006.01); A61K 8/46 (2006.01); A61K 8/55 (2006.01); A61K 8/73 (2006.01); A61K 8/92 (2006.01); A61K 8/9789 (2017.01); A61K 8/98 (2006.01); A61Q 11/00 (2006.01); A61K 38/00 (2006.01)
CPC A61K 8/64 (2013.01) [A23G 3/44 (2013.01); A23G 4/14 (2013.01); A23L 33/18 (2016.08); A61K 8/0204 (2013.01); A61K 8/11 (2013.01); A61K 8/19 (2013.01); A61K 8/25 (2013.01); A61K 8/345 (2013.01); A61K 8/442 (2013.01); A61K 8/463 (2013.01); A61K 8/553 (2013.01); A61K 8/73 (2013.01); A61K 8/922 (2013.01); A61K 8/9789 (2017.08); A61K 8/987 (2013.01); A61Q 11/00 (2013.01); A23V 2002/00 (2013.01); A61K 38/00 (2013.01)] 16 Claims
 
1. A method for treating a tooth of a subject, comprising applying a dental care product to a plurality of teeth of a subject, wherein the dental care product comprises
(i) self-assembling peptides comprising the sequence of SEQ ID NO: 4 and having at least 80% sequence identity to one of the sequences of SEQ ID NO: 1 or 2, wherein the self-assembling peptides are present in the dental care product in monomeric form, and
(ii) a pharmaceutically acceptable base,
wherein the pH of the dental care product is not buffered but instead wherein the dental care product is solid with a water content low enough to prevent self-assembly of the self-assembling peptides,
wherein the dental care product is applied to a plurality of teeth of the subject independent of diagnosis of caries,
wherein the subject has an early subsurface caries lesion,
wherein the concentration of self-assembling peptides is 0.1-1000 mg/kg,
and wherein, after application, self-assembling peptides are present in monomeric state for at least 1 minute.