| CPC A61B 17/22 (2013.01) [A61M 1/77 (2021.05); A61B 2017/00292 (2013.01); A61B 2017/22079 (2013.01); A61M 2205/3331 (2013.01)] | 20 Claims |

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1. An aspiration thrombectomy system, comprising:
an aspiration catheter;
connection tubing configured to place a vacuum source and the aspiration catheter in fluid communication;
one or more controllable valves configured to control a level of negative pressure provided by the vacuum source;
one or more sensors associated with the aspiration thrombectomy system, wherein one or more of the sensors are ultrasonic sensors configured to detect ultrasonic energy in the aspiration catheter or the connection tubing; and
an automated controller configured to:
generate, via one or more of the controllable valves, while the aspiration thrombectomy system is being operated in a first operational state, a pressure wave in fluidic content in the aspiration catheter or the connection tubing;
detect, via one or more of the ultrasonic sensors, responsive to the pressure wave being generated, ultrasonic energy from the fluidic content in the aspiration catheter or the connection tubing based on ultrasonic energy originating from the one or more ultrasonic sensors;
determine, based at least in part on the generated pressure wave and the detected ultrasonic energy, a system state in the aspiration catheter or the connecting tubing; and
operate, based on the determined system state, the aspiration thrombectomy system in a second operational state.
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