US 12,484,834 B2
Ketogenic dietary evaluation system and operation method thereof
Pi-Lien Hung, Kaohsiung (TW); and Syu-Jyun Peng, Zhubei (TW)
Assigned to Kaohsiung Chang Gung Memorial Hospital, Kaohsiung (TW); and Taipei Medical University (TMU), Taipei (TW)
Filed by Kaohsiung Chang Gung Memorial Hospital, Kaohsiung (TW); and Taipei Medical University (TMU), Taipei (TW)
Filed on Nov. 2, 2022, as Appl. No. 17/979,162.
Claims priority of application No. 110140849 (TW), filed on Nov. 2, 2021.
Prior Publication US 2023/0134678 A1, May 4, 2023
Int. Cl. A61B 5/369 (2021.01); A61B 5/00 (2006.01)
CPC A61B 5/369 (2021.01) [A61B 5/4094 (2013.01); A61B 5/7203 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A ketogenic diet evaluation system, comprising:
a storage device configured to store at least one instruction, a plurality of electroencephalogram data of a responder group and a plurality of electroencephalogram data of a non-responder group, wherein each electroencephalogram datum of the electroencephalogram data of the responder group and the electroencephalogram data of the non-responder group comprises a plurality of electroencephalograms of a plurality of channels; and
a processor coupled to the storage device, and the processor configured to access and execute the at least one instruction for:
preprocessing the electroencephalograms of the channels to obtain a plurality of preprocessed electroencephalograms of the channels;
obtaining a connectivity matrix based on a phase synchronization between each two of the preprocessed electroencephalograms of the channels;
sampling and analyzing the connectivity matrix through different frequency bands and different proportion threshold values to obtain a plurality of network parameters; and
establishing a predictive model based on a reduction rate of a predetermined event of the responder group, a reduction rate of the predetermined event of the non-responder group and the network parameters;
analyzing a plurality of new electroencephalograms of the channels based on the predictive model to determine whether the new electro electroencephalograms is are inclined to the response group or the non-response group and to provide a determination result accordingly;
determining whether a seizure rate is reduced after ketogenic diet.