US 12,484,576 B2
Blood preservation compositions, devices, and uses thereof
Beverly A. Rzigalinski, Blacksburg, VA (US); and Siva Sai Ramana Kumar Challa, Newton, MA (US)
Assigned to EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE, Blacksburg, VA (US); and MILLIFLUIDICA LLC, Baton Rouge, LA (US)
Appl. No. 17/263,526
Filed by EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE, Blacksburg, VA (US); and Siva Sai Ramana Kumar Challa, Newton, MA (US)
PCT Filed Jul. 26, 2019, PCT No. PCT/US2019/043785
§ 371(c)(1), (2) Date Jan. 26, 2021,
PCT Pub. No. WO2020/023932, PCT Pub. Date Jan. 30, 2020.
Claims priority of provisional application 62/703,474, filed on Jul. 26, 2018.
Prior Publication US 2021/0235690 A1, Aug. 5, 2021
Int. Cl. A01N 1/10 (2025.01); A01N 1/12 (2025.01); A01N 1/126 (2025.01); A01N 1/146 (2025.01); A61J 1/06 (2006.01); A61J 1/10 (2006.01); A61L 27/30 (2006.01); A61L 27/58 (2006.01); B82Y 5/00 (2011.01); B82Y 30/00 (2011.01); B82Y 40/00 (2011.01)
CPC A01N 1/146 (2025.01) [A01N 1/12 (2025.01); A01N 1/126 (2025.01); A61J 1/065 (2013.01); A61J 1/10 (2013.01); A61L 27/306 (2013.01); A61L 27/58 (2013.01); B82Y 5/00 (2013.01); B82Y 30/00 (2013.01); B82Y 40/00 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A blood storage container comprising:
a blood storage container object surface; and
cerium oxide nanoparticles (CeONPs) present in an amount to yield a concentration of CeNOPs of 10 nM to 100 nM in a blood, blood product(s), components thereof, or any combination thereof when stored in the blood storage container that is effective to (a) maintain an ATP concentration of at least 4.0 μmols/gHb in the blood, blood product(s), components thereof, or any combination thereof when stored in the blood storage container for 28 days at 4 degrees C. (b) maintain an ATP concentration of at least 2.8 μmols/gHb in the blood, blood product(s), components thereof, or any combination thereof when stored in the blood storage container for 42 days at 4 degrees C.; or (c) both (a) and (b) thereby increasing the useful storage life of blood, blood product(s), components thereof, or any combination thereof when stored in the blood storage container.