US 12,154,662 B2
Method of analyzing nucleic acid sequence of patient sample, presentation method, presentation apparatus, and presentation program of analysis result, and system for analyzing nucleic acid sequence of patient sample
Kenichiro Suzuki, Kobe (JP); Reiko Watanabe, Kobe (JP); Mizuho Kawate, Kobe (JP); Kosuke Kai, Kobe (JP); and Hiroko Onoe, Kobe (JP)
Assigned to SYSMEX CORPORATION, Kobe (JP)
Filed by SYSMEX CORPORATION, Kobe (JP)
Filed on Jun. 19, 2020, as Appl. No. 16/906,269.
Claims priority of application No. 2019-114139 (JP), filed on Jun. 19, 2019.
Prior Publication US 2020/0402611 A1, Dec. 24, 2020
Int. Cl. G16B 20/20 (2019.01); C12Q 1/6869 (2018.01); C12Q 1/6883 (2018.01); C12Q 1/6886 (2018.01); G06F 40/174 (2020.01); G16B 30/00 (2019.01); G16H 15/00 (2018.01)
CPC G16B 20/20 (2019.02) [C12Q 1/6869 (2013.01); C12Q 1/6883 (2013.01); C12Q 1/6886 (2013.01); G06F 40/174 (2020.01); G16B 30/00 (2019.02); G16H 15/00 (2018.01); C12Q 2600/118 (2013.01); C12Q 2600/156 (2013.01)] 23 Claims
 
1. An analysis method of analyzing a nucleic acid sequence of a patient sample with a computer, comprising:
sequencing a tumor cell collected from a patient to create first nucleic acid sequence data;
sequencing a non-tumor cell collected from the patient to create second nucleic acid sequence data;
obtaining the first nucleic acid sequence data, and the second nucleic acid sequence data;
detecting a somatic mutation based on analyzing the first nucleic acid sequence data;
detecting a germline mutation based on analyzing the second nucleic acid sequence data;
selecting a presentation form for presenting information on the germline mutation of the patient among different candidate forms for presenting analysis reports for the patient; and
creating an analysis report for the patient in the selected presentation form, wherein
the candidate forms comprise a first form that presents the analysis report in a form that excludes at least part of the information on the germline mutation of the patient and a second form that presents the analysis report in a form that includes the information on the germline mutation of the patient; and
selecting the presentation form comprises selecting among the first form and the second form based on a selection criteria that indicates a permissible presentation form of the information on the germline mutation.