US 12,152,068 B2
Binding moieties for biofilm remediation
Lawrence M. Kauvar, San Francisco, CA (US); Stefan Ryser, Menlo Park, CA (US); Angeles Estelles, Belmont, CA (US); Reyna J. Simon, Los Gatos, CA (US); Lauren Opremcak Bakaletz, Columbus, OH (US); and Steven David Goodman, Columbus, OH (US)
Assigned to Trellis Bioscience, LLC, Redwood City, CA (US)
Filed by TRELLIS BIOSCIENCE, LLC, Redwood City, CA (US)
Filed on Jan. 5, 2022, as Appl. No. 17/569,377.
Application 16/746,708 is a division of application No. 16/181,260, filed on Nov. 5, 2018, granted, now 10,570,193, issued on Feb. 25, 2020.
Application 16/181,260 is a division of application No. 15/144,681, filed on May 2, 2016, granted, now 10,233,234, issued on Mar. 19, 2019.
Application 17/569,377 is a continuation of application No. 16/746,708, filed on Jan. 17, 2020, granted, now 11,248,040.
Application 15/144,681 is a continuation in part of application No. 15/042,061, filed on Feb. 11, 2016, abandoned.
Application 15/144,681 is a continuation in part of application No. 14/789,842, filed on Jul. 1, 2015, abandoned.
Application 15/042,061 is a continuation in part of application No. 14/668,767, filed on Mar. 25, 2015, abandoned.
Application 14/668,767 is a continuation in part of application No. 14/497,147, filed on Sep. 25, 2014, abandoned.
Claims priority of provisional application 61/926,828, filed on Jan. 13, 2014.
Claims priority of provisional application 61/883,078, filed on Sep. 26, 2013.
Prior Publication US 2022/0259294 A1, Aug. 18, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/12 (2006.01); A61K 35/12 (2015.01); A61K 39/00 (2006.01); A61K 39/40 (2006.01); A61K 45/06 (2006.01); A61K 49/00 (2006.01); C07K 14/31 (2006.01); C12N 15/86 (2006.01); C12Q 1/18 (2006.01); G01N 33/566 (2006.01); G01N 33/569 (2006.01)
CPC C07K 16/1271 (2013.01) [A61K 39/40 (2013.01); A61K 45/06 (2013.01); A61K 49/00 (2013.01); C07K 14/31 (2013.01); C07K 16/1214 (2013.01); C07K 16/1228 (2013.01); C07K 16/1242 (2013.01); C07K 16/1275 (2013.01); C12Q 1/18 (2013.01); G01N 33/566 (2013.01); G01N 33/56911 (2013.01); A61K 35/12 (2013.01); A61K 39/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2319/00 (2013.01); C12N 15/86 (2013.01); G01N 2333/195 (2013.01); G01N 2333/21 (2013.01); G01N 2333/245 (2013.01); G01N 2333/26 (2013.01); G01N 2333/285 (2013.01); G01N 2469/10 (2013.01)] 18 Claims
 
1. A monoclonal antibody (mAb) or antigen binding fragment thereof that specifically binds a DNA binding protein II (DNABII), wherein the mAb or antigen binding fragment thereof comprises:
a heavy chain variable region (SEQ ID NO:1) and a light chain variable region (SEQ ID NO: 2) of TRL1068;
a heavy chain variable region (SEQ ID NO:21) and a light chain variable region (SEQ ID NO: 22) of TRL1330; or,
a heavy chain variable region (SEQ ID NO:25) and a light chain variable region (SEQ ID NO: 26) of TRL1337.