US 12,152,021 B2
Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component
Youn Ho Lee, Incheon (KR); Ju Hee Kang, Incheon (KR); Se In Kang, Incheon (KR); Yi Kyung Ko, Incheon (KR); Eun Hwa Ko, Incheon (KR); Hwan Geun Choi, Seoul (KR); Jung Beom Son, Incheon (KR); and Nam Doo Kim, Incheon (KR)
Assigned to VORONOI INC., Incheon (KR)
Appl. No. 17/440,630
Filed by VORONOI INC., Incheon (KR)
PCT Filed Mar. 19, 2020, PCT No. PCT/KR2020/095044
§ 371(c)(1), (2) Date Sep. 17, 2021,
PCT Pub. No. WO2020/190119, PCT Pub. Date Sep. 24, 2020.
Claims priority of application No. 10-2019-0031269 (KR), filed on Mar. 19, 2019; and application No. 10-2019-0134472 (KR), filed on Oct. 28, 2019.
Prior Publication US 2022/0162203 A1, May 26, 2022
Int. Cl. C07D 413/14 (2006.01); A61K 31/407 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/5386 (2006.01); A61P 35/00 (2006.01); C07D 409/14 (2006.01); C07D 413/04 (2006.01); C07D 417/04 (2006.01); C07D 471/04 (2006.01); C07D 471/18 (2006.01); C07D 487/04 (2006.01); C07D 487/08 (2006.01); C07D 491/048 (2006.01); C07D 491/08 (2006.01); C07D 491/107 (2006.01); C07D 498/08 (2006.01)
CPC C07D 413/14 (2013.01) [A61P 35/00 (2018.01); C07D 413/04 (2013.01); C07D 487/08 (2013.01); C07D 498/08 (2013.01)] 29 Claims
 
1. A compound of Formula 8,

OG Complex Work Unit Chemistry
wherein:
R5 is C1-8 alkyl, aryl of 3 to 12 atoms, heteroaryl of 3 to 12 atoms, or heterocycloalkyl of 3 to 12 atoms, wherein the C1-8 alkyl, aryl, heteroaryl, and heterocycloalkyl are independently unsubstituted or substituted by at least one substituent J;
J is selected from the group consisting of halogen, cyano, C1-8 alkyl substituted or unsubstituted by halogen, aryl of 3 to 12 atoms, heteroaryl of 3 to 12 atoms, heterocycloalkyl of 3 to 12 atoms, C2-8 alkenyl, C1-8 alkoxy, C2-8 alkynyl and C1-8 alkylamino, wherein each of the substituents J are independently unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, C1-8 alkyl substituted or unsubstituted by halogen, C1-8 alkoxy, and C1-8 alkylamino;
R6 is hydrogen or C1-8 alkyl; and
G is halogen, a sulfonic acid, an ester, or an alkoxy.