	US 12,151,033 B2
	Foam compositions, foam matrices and methods
Vyacheslav Dudnyk, Mississauga (CA); Mirzo Kanoatov, Toronto (CA); and Valerio Ditizio, Toronto (CA)
Assigned to COVALON TECHNOLOGIES INC., Mississauga (CA)
Filed by COVALON TECHNOLOGIES INC., Mississauga (CA)
Filed on Dec. 5, 2022, as Appl. No. 18/075,283.
Application 18/075,283 is a continuation of application No. 16/671,975, filed on Nov. 1, 2019, granted, now 11,517,644.
Claims priority of provisional application 62/754,698, filed on Nov. 2, 2018.
Prior Publication US 2023/0241282 A1, Aug. 3, 2023
Int. Cl. A61L 15/42 (2006.01); A61L 15/22 (2006.01); A61L 15/32 (2006.01); A61L 15/44 (2006.01); A61L 15/64 (2006.01); C08J 9/12 (2006.01)

CPC A61L 15/425 (2013.01) [A61L 15/225 (2013.01); A61L 15/32 (2013.01); A61L 15/44 (2013.01); A61L 15/64 (2013.01); C08J 9/125 (2013.01); A61L 2300/404 (2013.01); A61L 2300/418 (2013.01); A61L 2400/04 (2013.01); C08J 2203/10 (2013.01); C08J 2389/04 (2013.01); C08J 2405/04 (2013.01)]

14 Claims

1. A method for making a matrix, the method comprising:

foaming a composition comprising a biomolecule and a biocompatible polymer, wherein the biomolecule is selected from the group consisting of gelatin, collagen, elastin, and combinations thereof, and the biocompatible polymer is selected from the group consisting of polyethylene glycol, poly-L-lysine, alginate, chitosan, hyaluronic acid, chondroitin sulfate, pectin, cellulose, carboxymethylcellulose and mixtures thereof;

crosslinking the foamed composition; and

drying the composition, to prepare the matrix, wherein the biomolecule and biocompatible polymer are evenly distributed throughout the matrix; wherein the matrix is a dried, cross-linked foam; wherein the biomolecule is present in an amount of from about 40% to about 80% (w/w) by the weight of said matrix; and wherein the matrix is non-lyophilized and has an absorption capacity of from about 20 times to about 50 times a dry weight of the matrix.