	US 12,151,018 B2
	Composition for inhibiting release of neurotransmitters
Woo-Seon Hwang, Seoul (KR); Yun-Sun Kim, Seoul (KR); Mu-Hyun Jin, Seoul (KR); and Nae-Gyu Kang, Seoul (KR)
Assigned to LG HOUSEHOLD & HEALTH CARE LTD., Seoul (KR)
Appl. No. 17/432,768
Filed by LG HOUSEHOLD & HEALTH CARE LTD., Seoul (KR)
PCT Filed Feb. 20, 2020, PCT No. PCT/KR2020/095007 § 371(c)(1), (2) Date Oct. 29, 2021, PCT Pub. No. WO2020/171682, PCT Pub. Date Aug. 27, 2020.
Claims priority of application No. 10-2019-0021265 (KR), filed on Feb. 22, 2019; and application No. 10-2020-0002573 (KR), filed on Jan. 8, 2020.
Prior Publication US 2022/0142908 A1, May 12, 2022
Int. Cl. A61K 8/9789 (2017.01); A61Q 19/08 (2006.01)

CPC A61K 8/9789 (2017.08) [A61Q 19/08 (2013.01)]

9 Claims

1. A method for inhibiting neurotransmitter secretion, comprising applying a composition comprising a combination of (i) a Zanthoxylum piperitum fruit extract and (ii) a SNARE formation inhibitor as an active ingredient to a subject in need thereof,

wherein the SNARE formation inhibitor is argireline, botulinum neurotoxin type A light chain (BoNT/A LC), or a mixture thereof, and

wherein a weight of the comprised Zanthoxylum piperitum fruit extract is equal to or greater than a weight of the SNARE formation inhibitor.