US 12,151,010 B2
Skin lightening agent
Shoko Sassa, Kanagawa (JP); Yasuhito Mori, Kanagawa (JP); and Yuko Saitoh, Kanagawa (JP)
Assigned to POLA CHEMICAL INDUSTRIES, INC., Shizuoka (JP)
Appl. No. 17/057,320
Filed by POLA CHEMICAL INDUSTRIES, INC., Shizuoka (JP)
PCT Filed Apr. 24, 2019, PCT No. PCT/JP2019/017350
§ 371(c)(1), (2) Date Nov. 20, 2020,
PCT Pub. No. WO2019/230274, PCT Pub. Date Dec. 5, 2019.
Claims priority of application No. 2018-101963 (JP), filed on May 29, 2018.
Prior Publication US 2021/0196599 A1, Jul. 1, 2021
Int. Cl. A61K 8/44 (2006.01); A61Q 19/02 (2006.01)
CPC A61K 8/44 (2013.01) [A61Q 19/02 (2013.01); A61K 2800/434 (2013.01)] 3 Claims
 
1. A method of skin whitening comprising:
applying an agent comprising a compound expressed by the following Formula (1), or an acid addition salt thereof:

OG Complex Work Unit Chemistry
 (wherein, X represents an alkylene group having 1 to 2 carbon atoms, where a hydrogen atom may be substituted with a methyl group; Y represents COOR1 or CH2OR2; R1 represents a hydrogen atom, or an optionally branched alkyl group having 1 to 6 carbon atoms; and R2 represents a hydrogen atom or an optionally branched acyl group having 1 to 6 carbon atoms).