CPC A61K 47/55 (2017.08) [A61K 47/545 (2017.08)] | 15 Claims |
1. A compound of formula I-d-5:
![]() or a pharmaceutically acceptable salt thereof, wherein:
each Rx is independently —OC1-6 aliphatic or —CR2(OR);
each R is independently hydrogen or C1-6 aliphatic;
each Ry is independently Rz, fluoro, chloro, —CN, or —OR;
each Rz is a C1-6 aliphatic optionally substituted with one or more fluoro;
Ring T is selected from phenyl or a 5-9 membered mono- or bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, wherein Ring T is further optionally substituted with 1-2 oxo groups;
Lx is —C(O)N(H)—, wherein either the carbon or nitrogen atom of —C(O)N(H)— is attached to Ring T;
X is a covalent bond
![]() x is 0 or 1;
y is 0, 1, or 2;
L is a covalent bond or a bivalent, saturated or unsaturated, straight or branched C1-30 hydrocarbon chain, wherein 0-6 methylene units of L are independently replaced by -Cy-, —CRF—, —CF2—, —O—, —N(R)—, —OC(O)—, —C(O)O—, —C(O)—, —S(O)—, —S(O)2—, —N(R)S(O)2—, —S(O)2N(R)—, —N(R)C(O)—, —C(O)N(R)—, —OC(O)N(R)—, —N(R)C(O)O—, wherein
each -Cy- is independently an optionally substituted bivalent ring selected from a 4-7 membered saturated or partially unsaturated carbocyclylenyl, a 4-11 membered saturated or partially unsaturated spiro carbocyclylenyl, a 4-7 membered saturated or partially unsaturated heterocyclylenyl having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, a 4-11 membered saturated or partially unsaturated spiro heterocyclylenyl having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or an 8-10 membered bicyclic saturated or partially unsaturated heterocyclylenyl having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and
DIM is a degradation inducing moiety selected from a cereblon E3 ubiquitin ligase binding moiety of formula I-ccc-1:
![]() or a pharmaceutically acceptable salt thereof, wherein:
X1 is —C(O)—;
X2a is —C(O)—;
X3a is —CH2— or —C(O)—;
R1 is hydrogen;
each of R2 is independently fluoro, chloro, C1-4 aliphatic, or —OC1-4 aliphatic;
Ring Aa is a fused 6-membered aryl containing 0-1 nitrogen atoms; and
m is 0, or 1.
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