US 12,150,988 B2
Storage improved poxvirus compositions
Katrine Kjaer, Brønshøj (DK); and Kerstin Mammeri, Hennigsdorf (DE)
Assigned to Bavarian Nordic A/S, Hellerup (DK)
Appl. No. 17/273,977
Filed by Bavarian Nordic A/S, Hellerup (DK)
PCT Filed Sep. 6, 2019, PCT No. PCT/EP2019/073825
§ 371(c)(1), (2) Date Mar. 5, 2021,
PCT Pub. No. WO2020/049151, PCT Pub. Date Mar. 12, 2020.
Claims priority of application No. 18192857 (EP), filed on Sep. 6, 2018.
Prior Publication US 2021/0187100 A1, Jun. 24, 2021
Int. Cl. A61K 39/285 (2006.01); C12N 7/00 (2006.01)
CPC A61K 39/285 (2013.01) [C12N 7/00 (2013.01); C12N 2710/24134 (2013.01)] 19 Claims
 
1. An aqueous live poxvirus composition that comprises:
(a) at least one live poxvirus,
(b) at least one disaccharide selected from trehalose and sucrose at a concentration between 4% (w/v) and 12% (w/v),
(c) sorbitol at a concentration between 1% (w/v) and 3% (w/v),
(d) gelatin hydrolysate at a concentration between 0.2% (w/v) and 4% (w/v),
(e) albumin at a concentration between 0.2% (w/v) and 1.2% (w/v),
(f) a pharmaceutical acceptable buffer, and
(g) at least one monovalent salt,
wherein said composition has a pH between pH 7.3 and pH 8.1.