a housing; and

a biopsy needle extending from the housing, the biopsy needle including an outer cutting needle and an inner sample needle with a tissue compartment for receiving a tissue sample, the outer cutting needle surrounding the inner sample needle, the outer cutting needle and the inner sample needle being arranged slidingly in relation to each other along their longitudinal direction, the outer cutting needle having a cutting end distant from the housing, and

wherein the biopsy device is adapted to, during a sampling operation whereby a tissue sample is collected in the tissue compartment of the inner sample needle, displace the outer cutting needle and the inner sample needle at least between an open position of the tissue compartment in which the tissue compartment extends beyond the cutting end of the outer cutting needle and a closed position of the tissue compartment in which the outer cutting needle covers the tissue compartment,

wherein the biopsy device includes a vacuum source for providing a pressure decrease in the tissue compartment of the inner sample needle via a vacuum channel arranged longitudinally in the biopsy needle, and

wherein the biopsy device includes a valve system adapted to provide a pressure decrease in the tissue compartment during the sampling operation, wherein the vacuum source includes a number of initially pre-evacuated vacuum containers, in that the biopsy device is adapted to, by use of a vacuum of the number of initially pre-evacuated vacuum containers, provide a pressure decrease in the tissue compartment of the inner sample needle during each one of a limited number of consecutive sampling operations, the valve system is adapted to connect each of the number of initially pre-evacuated vacuum containers separately and in succession, corresponding to the respective one of the limited number of consecutive sampling operations, with the vacuum channel in the biopsy needle; and

wherein each of the initially pre-evacuated vacuum containers is connected to a vacuum valve having a valve membrane, and wherein the valve system includes a hollow vacuum needle having a needle tip adapted to penetrate the valve membrane of the vacuum valve.