US 12,482,572 B2
Method for detecting an infectious transmission in a population
Jean-Philippe Rasigade, Lyons (FR)
Assigned to HOSPICES CIVILS DE LYON, Lyons (FR); UNIVERSITE CLAUDE BERNARD LYON 1, Villeurbanne (FR); ECOLE NORMALE SUPERIEURE DE LYON, Lyons (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Paris (FR); and INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), Paris (FR)
Appl. No. 18/252,831
Filed by HOSPICES CIVILS DE LYON, Lyons (FR); UNIVERSITE CLAUDE BERNARD LYON 1, Villeurbanne (FR); ECOLE NORMALE SUPERIEURE DE LYON, Lyons (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Paris (FR); and INSERM (Institut National de la Sante et de la Recherche Medicale), Paris (FR)
PCT Filed Nov. 16, 2021, PCT No. PCT/FR2021/052021
§ 371(c)(1), (2) Date May 12, 2023,
PCT Pub. No. WO2022/101596, PCT Pub. Date May 19, 2022.
Claims priority of application No. 2011693 (FR), filed on Nov. 16, 2020.
Prior Publication US 2024/0006082 A1, Jan. 4, 2024
Int. Cl. G16H 50/80 (2018.01); G16B 20/00 (2019.01); G16B 40/10 (2019.01); G16H 10/40 (2018.01); G16H 70/60 (2018.01)
CPC G16H 50/80 (2018.01) [G16B 20/00 (2019.02); G16B 40/10 (2019.02); G16H 10/40 (2018.01); G16H 70/60 (2018.01)] 16 Claims
OG exemplary drawing
 
1. A method for detecting an infectious transmission in a population, implemented by data processing means (20) of a client (2), the method comprising:
(b) receiving from a server (1) comprising data storage media (4) storing a database of infectious agent isolates, a plurality of infectious agent isolates each associated with an individual of a population, each infectious agent isolate being defined by a vector with values descriptive of the isolate, the vector comprising a resistance profile of the isolate and/or a list of protein peaks of the isolate;
(c) for each pair of a first isolate (X) and a second isolate (Y) of the plurality respectively associated with a first individual and a second individual of the population:
(c1) calculating a first number of isolates (n(X)) corresponding to the number of isolates of the plurality having a distance to the first isolate (X) less than or equal to a reference distance between the first and second isolates (X, Y), and a second number of isolates (n(Y)) corresponding to the number of isolates of said plurality having a distance to the second isolate (Y) less than or equal to the reference distance between the first and second isolates (X, Y), each distance between two isolates being representative of a dissimilarity between the vectors of values descriptive of these two isolates;
(c2) estimating a probability (TXY) of direct infectious transmission between the first and second individuals as a function of the first and second number of isolates (n(X), n(Y));
(d) detecting or not detecting an infectious transmission in the population as a function of the estimated probabilities (TXY) of direct infectious transmission between each pair of individuals.