US 12,482,281 B2
Cell selection apparatus and method
Do Hyun Kim, Seoul (KR); Sung Won Kim, Seoul (KR); Seung Ki Kwok, Seoul (KR); Jeong Ho Chun, Seoul (KR); Jae Seon Lee, Seoul (KR); Seungchul Lee, Pohang-si (KR); and Gyu Won Kim, Pohang-si (KR)
Assigned to THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Seoul (KR); and POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION, Pohang-si (KR)
Appl. No. 18/021,470
Filed by THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Seoul (KR); and POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION, Pohang-si (KR)
PCT Filed Nov. 25, 2021, PCT No. PCT/KR2021/017471
§ 371(c)(1), (2) Date Feb. 15, 2023,
PCT Pub. No. WO2022/131607, PCT Pub. Date Jun. 23, 2022.
Claims priority of application No. 10-2020-0174709 (KR), filed on Dec. 14, 2020.
Prior Publication US 2023/0334882 A1, Oct. 19, 2023
Int. Cl. G06V 20/69 (2022.01); G06V 10/774 (2022.01); G06V 10/776 (2022.01)
CPC G06V 20/695 (2022.01) [G06V 10/774 (2022.01); G06V 10/776 (2022.01); G06V 20/698 (2022.01)] 10 Claims
OG exemplary drawing
 
1. A cell selection device, comprising:
a pre-processing unit adjusting a size of a cell image extracted from image data obtained by capturing a cell into a preset size, converting the resized cell image into an HSV color space (hue, saturation, value model) to correct a brightness value, and normalizing a pixel value to generate training data;
a model generation unit generating a second learning model by performing transfer learning using at least two different pre-trained first learning models and combining outputs of the first learning models based on a similarity between the training data and the datasets of the first learning models;
a cell classification unit determining a homogeneity of the cell based on the number of specific single cells inferred as functional cells using the second learning model from the cell image and classifying the cell into a positive cell and a negative cell based on the homogeneity; and
a visualization unit marking a portion serving as a classification reference on the cell image based on a result of the classification by the second learning model and outputting the marked image to indicate a basis of the classification.