US 12,480,161 B1
Identification of microRNA biomarkers for diagnosis and treatment for Sleep Apnea
Abdulmohsen Alterki, Kuwait (KW); Fahd Al-Mulla, Kuwait (KW); Jehad Ahmed Abubaker, Kuwait (KW); and Mohamed Abu-Farha, Kuwait (KW)
Assigned to Sabah Al-Ahmad Center for Giftedness and Creativity, Safat (KW); and Dasman Diabetes Institute, Dasman (KW)
Filed by Sabah Al-Ahmad Center for Giftedness and Creativity, Safat (KW); and Dasman Diabetes Institute, Dasman (KW)
Filed on May 1, 2025, as Appl. No. 19/196,434.
Int. Cl. C12Q 1/6883 (2018.01); C07H 21/04 (2006.01)
CPC C12Q 1/6883 (2013.01) [C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of diagnosing and treating sleep apnea in a subject, the method comprising:
determining whether the subject needs a polysomnography by:
obtaining a biological sample from the subject;
determining if the subject has a microRNA selected from the group consisting of miRNA-30b-5p, miRNA-30c-5p, miRNA-19b-3p, and miRNA-23b-5p by testing the biological sample for the presence of a miRNA at least 95% identical to a microRNA sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, and SEQ ID NO: 4, wherein expression of one of the microRNA is associated with the presence of SA in a subject;
conducting a Polysomnography (PSG) on the subject to further determine if the subject has SA; and
treating the subject with a treatment of SA selected from the group consisting of ENT multilevel surgery, continuous positive airway pressure (CPAP) therapy, and bariatric surgery.