	US 12,479,902 B2
	T cell receptors recognizing R175H or Y220C mutation in P53
Drew C. Deniger, Houston, TX (US); Parisa Malekzadeh, Norfolk, VA (US); and Steven A. Rosenberg, Potomac, MD (US)
Assigned to The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US)
Appl. No. 17/620,942
Filed by The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US)
PCT Filed Jun. 26, 2020, PCT No. PCT/US2020/039785 § 371(c)(1), (2) Date Dec. 20, 2021, PCT Pub. No. WO2020/264269, PCT Pub. Date Dec. 30, 2020.
Claims priority of provisional application 62/867,619, filed on Jun. 27, 2019.
Prior Publication US 2022/0332785 A1, Oct. 20, 2022
Int. Cl. C07K 14/725 (2006.01); A61K 38/00 (2006.01); A61K 40/11 (2025.01); A61K 40/32 (2025.01); A61K 40/42 (2025.01); G01N 33/574 (2006.01)

CPC C07K 14/7051 (2013.01) [A61K 40/11 (2025.01); A61K 40/32 (2025.01); A61K 40/4201 (2025.01); G01N 33/5748 (2013.01); A61K 38/00 (2013.01); G01N 2333/4748 (2013.01); G01N 2333/7051 (2013.01)]

35 Claims

1. An isolated or purified T cell receptor (TCR) having antigenic specificity for a human p53^Y220Camino acid sequence, wherein the TCR comprises the amino acid sequences of all of SEQ ID NOs: 80-85.