US 12,479,871 B2
Method of preparing symmetrical phosphate-based compound
Dae Hwan Yoo, Gyeonggi-do (KR); Jae Yeol Ma, Gyeonggi-do (KR); Seok Jong Lee, Gyeonggi-do (KR); Kwang Ju Jung, Gyeonggi-do (KR); and Weon Ju Yu, Gyeonggi-do (KR)
Assigned to SOULBRAIN CO., LTD., Gyeonggi-do (KR)
Appl. No. 18/033,728
Filed by SOULBRAIN CO., LTD., Gyeonggi-do (KR)
PCT Filed Oct. 28, 2021, PCT No. PCT/KR2021/015276
§ 371(c)(1), (2) Date Apr. 25, 2023,
PCT Pub. No. WO2022/092835, PCT Pub. Date May 5, 2022.
Claims priority of application No. 10-2020-0142168 (KR), filed on Oct. 29, 2020.
Prior Publication US 2023/0399349 A1, Dec. 14, 2023
Int. Cl. C07F 9/6574 (2006.01)
CPC C07F 9/65742 (2013.01) 16 Claims
 
1. A method of preparing a symmetrical phosphate-based compound, comprising synthesizing a compound represented by Chemical Formula 2 below by reacting a compound represented by Chemical Formula 1 below with a dinucleating agent in a hydrophobic solvent under a base-free condition, wherein the reaction is performed at 0 to 40° C.:

OG Complex Work Unit Chemistry
wherein, in Chemical Formulas 1 and 2, R is a substituted or unsubstituted alkylene having 1 to 3 carbon atoms; X is chlorine (Cl), bromine (Br), fluorine (F), or iodine (I); and n is an integer from 1 to 5, wherein a substituent is independently selected from a halogen, a hydroxyl group, an alkyl group having 1 to 8 carbon atoms, a heteroalkyl group having 3 to 6 carbon atoms, or an aryl group having 6 to 10 carbon atoms, and the alkyl group, heteroalkyl group, and aryl group are independently substituted with a halogen.