US 12,479,836 B2
Sphingosine-1-phosphate receptor agonist, preparation method therefor, and pharmaceutical composition containing same as active ingredient
Seung Yup Paek, Daejeon (KR); Deok Seong Park, Daejeon (KR); and Sang Yong Hong, Daejeon (KR)
Assigned to LG CHEM, LTD., Seoul (KR)
Appl. No. 17/780,908
Filed by LG CHEM, LTD., Seoul (KR)
PCT Filed Nov. 20, 2020, PCT No. PCT/KR2020/016468
§ 371(c)(1), (2) Date May 27, 2022,
PCT Pub. No. WO2021/112461, PCT Pub. Date Jun. 10, 2021.
Claims priority of application No. 10-2019-0159309 (KR), filed on Dec. 3, 2019.
Prior Publication US 2023/0047472 A1, Feb. 16, 2023
Int. Cl. C07D 405/14 (2006.01); A61P 37/02 (2006.01); C07D 405/12 (2006.01)
CPC C07D 405/14 (2013.01) [A61P 37/02 (2018.01); C07D 405/12 (2013.01)] 13 Claims
 
1. A compound represented by Formula 1, a pharmaceutically acceptable salt, or a stereoisomer thereof:

OG Complex Work Unit Chemistry
wherein
R1 is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, or alkynyl;
R2 is hydrogen, a substituted or unsubstituted alkyl, halogen, CN, CF3, or COCF3;
R3 and R4 are each independently hydrogen, a substituted or unsubstituted alkyl, alkenyl, alkynyl, or halogen;
R5A and R5B are each independently hydrogen, a substituted or unsubstituted alkyl, alkenyl, alkynyl, or —R6 (COOH), wherein R6 is a single bond, a substituted or unsubstituted alkylene, alkenylene, or alkynylene, and any one of R5A and R5B is-R6 (COOH); and optionally R5A and R5B bind to each other to form a ring, which is substituted with —R6 (COOH).