US 12,479,809 B2
Hydrazone amide derivative and application thereof in preparation of medicaments for preventing and treating alopecia
Dane Huang, Guangdong (CN); Chao Zhao, Guangdong (CN); Qiong Gu, Guangdong (CN); and Jun Xu, Guangdong (CN)
Assigned to SHENZHEN CELL INSPIRE PHARMACEUTICAL DEVELOPMENT CO., LTD., Guangdong (CN)
Filed by SHENZHEN CELL INSPIRE PHARMACEUTICAL DEVELOPMENT CO., LTD., Guangdong (CN)
Filed on Dec. 27, 2021, as Appl. No. 17/562,976.
Application 17/562,976 is a continuation of application No. PCT/CN2020/083076, filed on Apr. 2, 2020.
Claims priority of application No. 201910578833.9 (CN), filed on Jun. 28, 2019.
Prior Publication US 2022/0153713 A1, May 19, 2022
Int. Cl. C07D 277/56 (2006.01); A61P 17/14 (2006.01); C07C 251/76 (2006.01); C07D 211/58 (2006.01); C07D 213/75 (2006.01); C07D 213/85 (2006.01); C07D 217/06 (2006.01); C07D 277/82 (2006.01); C07D 295/185 (2006.01)
CPC C07D 277/56 (2013.01) [A61P 17/14 (2018.01); C07C 251/76 (2013.01); C07D 211/58 (2013.01); C07D 213/75 (2013.01); C07D 213/85 (2013.01); C07D 217/06 (2013.01); C07D 277/82 (2013.01); C07D 295/185 (2013.01)] 4 Claims
 
1. A method for stimulating hair follicle growth, comprising: administering to a subject in need thereof a compound having one of the following structures, or a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a pharmaceutically acceptable salt or a prodrug of the compound having one of the following structures:

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry