US 12,478,960 B2
Solid state ion selective electrodes
John M. Wallach, Diamond Bar, CA (US); and Xihai Mu, Eastvale, CA (US)
Assigned to Beckman Coulter, Inc., Brea, CA (US)
Filed by Beckman Coulter, Inc., Brea, CA (US)
Filed on Jan. 8, 2021, as Appl. No. 17/144,624.
Claims priority of provisional application 62/960,239, filed on Jan. 13, 2020.
Prior Publication US 2021/0213442 A1, Jul. 15, 2021
Int. Cl. G01N 27/403 (2006.01); B01L 3/00 (2006.01); G01N 33/487 (2006.01); G01N 33/84 (2006.01)
CPC B01L 3/502 (2013.01) [G01N 27/4035 (2013.01); G01N 33/48707 (2013.01); G01N 33/84 (2013.01); B01L 2200/026 (2013.01); B01L 2200/0689 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0861 (2013.01)] 6 Claims
OG exemplary drawing
 
1. A cartridge assembly comprising:
(a) a housing adapted to fit within a cartridge receiver of a biological testing system;
(b) a sample well defined by a depression within a top surface of the housing;
(c) a reservoir, wherein the reservoir is disposed within the housing and beneath the sample well, wherein the reservoir includes an amount of reference fluid therein, wherein the reference fluid is sealed within the reservoir and separated from the sample well;
(d) a reference transducer disposed within the sample well and in contact with the reservoir, wherein the reference transducer is configured to generate a reference electrical potential based upon contact with the reference fluid in the reservoir;
(e) a measurement transducer positioned within the sample well and embedded in the housing, wherein the measurement transducer is configured to generate a measurement electrical potential based upon contact with a sample fluid in the sample well; and
(f) a set of connectors on a bottom surface of the housing, wherein:
(i) a reference connector of the set of connectors passes from outside of the housing into the reservoir such that a proximal end of the reference connector is proximate to the reference transducer and a distal end of the reference connector is positioned outside the housing,
(ii) a proximal end of a measurement connector is coupled to the measurement transducer within the housing and a distal end of the measurement connector is positioned outside the housing,
wherein the set of connectors is configured to transmit the reference electrical potential and the measurement electrical potential to a processor of the biological testing system at the same time in parallel when the cartridge assembly is placed in the cartridge receiver.