	US 12,478,778 B2
	Hydrogel-based biomedical devices for therapeutic hydrogen treatment of skin and tissues and methods of using them
Diana Berman, Denton, TX (US); Jihyung Lee, Denton, TX (US); Vladimir Safonov, Granbury, TX (US); Donghui Zhu, Frisco, TX (US); and Marina Safonov, Granbury, TX (US)
Assigned to MAG AND BIO DYNAMICS INC., Granbury, TX (US)
Filed by MAG AND BIO DYNAMICS INC., Granbury, TX (US)
Filed on Jul. 26, 2019, as Appl. No. 16/523,826.
Claims priority of provisional application 62/703,680, filed on Jul. 26, 2018.
Prior Publication US 2020/0030598 A1, Jan. 30, 2020
Int. Cl. A61N 1/04 (2006.01); A61K 9/00 (2006.01); A61K 33/00 (2006.01); A61K 33/40 (2006.01); A61K 47/36 (2006.01); A61L 26/00 (2006.01); A61M 37/00 (2006.01); A61P 17/02 (2006.01)

CPC A61N 1/0496 (2013.01) [A61K 9/0014 (2013.01); A61K 33/00 (2013.01); A61K 33/40 (2013.01); A61K 47/36 (2013.01); A61L 26/0023 (2013.01); A61L 26/008 (2013.01); A61M 37/00 (2013.01); A61N 1/0416 (2013.01); A61P 17/02 (2018.01); A61M 2037/0007 (2013.01)]

11 Claims

1. A product of manufacture capable of generating hydrogen, the product of manufacture comprising:

(a) a hydrated hydrogel, wherein the hydrogel comprises about 1% (w/w) hyaluronic acid, and

(b) at least one cathode electrode and at least one anode electrode implanted within or upon the hydrogel, wherein the cathode and the anode electrode are comprised of graphene and are spaced sufficiently apart to generate an electrical current in the hydrogel sufficient to cause a hydrolysis reaction in the hydrogel,

wherein the product of manufacture is fabricated in the form of a pad, a dressing, or a patch.