US 12,478,767 B2
Urinary catheter treatment
Mark E. Meyerhoff, Ann Arbor, MI (US); Orsolya I. Lautner-Csorba, Ann Arbor, MI (US); Griffin Murray, Grosse Pointe Farms, MI (US); Gergely Lautner, Ann Arbor, MI (US); Alexander S. Yevzlin, Black Earth, WI (US); and Karthik Ramani, Ann Arbor, MI (US)
Assigned to The Regents of the University of Michigan, Ann Arbor, MI (US)
Appl. No. 17/916,491
Filed by THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US)
PCT Filed Mar. 31, 2021, PCT No. PCT/US2021/025147
§ 371(c)(1), (2) Date Sep. 30, 2022,
PCT Pub. No. WO2021/202709, PCT Pub. Date Oct. 7, 2021.
Claims priority of provisional application 63/004,259, filed on Apr. 2, 2020.
Prior Publication US 2023/0084608 A1, Mar. 16, 2023
Int. Cl. A61M 25/10 (2013.01); A61M 25/00 (2006.01)
CPC A61M 25/10 (2013.01) [A61M 25/0017 (2013.01); A61M 2025/105 (2013.01); A61M 2202/0275 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A method, comprising:
mixing a liquid carrier and a powder formulation including an S-nitrosothiol (RSNO) powder to form a nitric oxide generating solution;
within a predetermined time of mixing, introducing the nitric oxide generating solution into an inflatable and nitric oxide permeable balloon of a urinary catheter that is inserted in a patient;
draining the nitric oxide generating solution from the inflatable and nitric oxide permeable balloon;
mixing a second liquid carrier and a second powder formulation including an S-nitrosothiol (RSNO) powder to form a second nitric oxide generating solution; and
within a predetermined time of the draining and the mixing, introducing the second nitric oxide generating solution into the inflatable and nitric oxide permeable balloon of the urinary catheter that remains inserted in the patient.