US 12,478,711 B2
Composite sheets and medical implants comprising such sheets
Mark Kenneth Hazzard, Echt (NL); Noel L. Davison, Echt (NL); Mandy Maria Jozefina Wiermans, Echt (NL); Nicolaes Hubertus Maria De Bont, Echt (NL); and Loes Heleen Pluymen, Echt (NL)
Assigned to DSM IP ASSETS B.V., Maastricht (NL)
Appl. No. 18/718,647
Filed by DSM IP ASSETS B.V., Heerlen (NL)
PCT Filed Dec. 12, 2022, PCT No. PCT/EP2022/085372
§ 371(c)(1), (2) Date Jun. 11, 2024,
PCT Pub. No. WO2023/110744, PCT Pub. Date Jun. 22, 2023.
Claims priority of application No. 21214206 (EP), filed on Dec. 13, 2021.
Prior Publication US 2025/0032674 A1, Jan. 30, 2025
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/48 (2006.01); B32B 27/40 (2006.01)
CPC A61L 27/48 (2013.01) [B32B 27/40 (2013.01); A61L 2430/20 (2013.01); B32B 2255/02 (2013.01); B32B 2255/26 (2013.01); B32B 2262/0253 (2013.01); B32B 2270/00 (2013.01); B32B 2307/538 (2013.01); B32B 2307/546 (2013.01); B32B 2307/7265 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A composite sheet having a thickness of 25-250 μm and comprising:
(a) 10-70 mass %, based on the total mass of the composite sheet, of a knit fabric having thickness of 15-225 μm and comprising strands of 2-50 dtex, the strands comprising biocompatible polymer fibers, the strands comprising biocompatible polymer fibers, wherein the fabric comprises a thickness in a plurality of first locations, and pores in a plurality of second locations; and
(b) 30-90 mass %, based on the total mass of the composite sheet, of a polyurethane coating, wherein the polyurethane coating coats the fabric and fills the pores of the fabric such that the composite sheet is substantially impermeable to water; wherein
the composite sheet has a 1% secant modulus of from 1 to 100 MPa and a hardening transition point of from 5 to 75% in each of two orthogonal directions and the diagonal thereof.