US 12,478,709 B2
Medical hydrogel and preparation method and uses thereof
Bo Zhao, Beijing (CN); Pengfei Wei, Beijing (CN); Wei Zhao, Beijing (CN); Wei Jing, Beijing (CN); Leilei Xia, Beijing (CN); and Yanrui Zhao, Beijing (CN)
Assigned to Beijing Biosis Healing Biological Technology Co., Ltd., Beijing (CN)
Appl. No. 18/014,385
Filed by Beijing Biosis Healing Biological Technology Co., Ltd., Beijing (CN)
PCT Filed Jun. 10, 2021, PCT No. PCT/CN2021/099446
§ 371(c)(1), (2) Date Jan. 4, 2023,
PCT Pub. No. WO2022/217733, PCT Pub. Date Oct. 20, 2022.
Claims priority of application No. 202110402493.1 (CN), filed on Apr. 14, 2021.
Prior Publication US 2023/0256134 A1, Aug. 17, 2023
Int. Cl. A61L 24/00 (2006.01); A61L 24/04 (2006.01)
CPC A61L 24/0031 (2013.01) [A61L 24/0015 (2013.01); A61L 24/046 (2013.01); A61L 2300/232 (2013.01); A61L 2430/36 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A medical hydrogel comprising a hydrogel skeleton and a chelating agent chelated to the hydrogel skeleton;
the hydrogel skeleton is formed by the bonding of a polyethylene glycol derivative I and a polyethylene glycol derivative II, the structure of the polyethylene glycol derivative I is shown in Formula (I):

OG Complex Work Unit Chemistry
the structure of the polyethylene glycol derivative II is shown in Formula (II):

OG Complex Work Unit Chemistry
wherein, m and n are natural numbers; the molecular weight of the polyethylene glycol derivative I is 2000 to 20000; the molecular weight of the polyethylene glycol derivative II is 2000 to 20000;
the chelating agent is selected from tannic acid and/or citric acid.