US 12,478,690 B2
Methods and systems for controlled release of drug cargo via ATP-responsive liposomes
Jinchao Lou, Knoxville, TN (US); Jennifer Schuster, Knoxville, TN (US); Francisco Nicolas Barrera Olivares, Knoxville, TN (US); and Michael Douglas Best, Knoxville, TN (US)
Filed by UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, Knoxville, TN (US)
Filed on Aug. 1, 2022, as Appl. No. 17/878,467.
Claims priority of provisional application 63/203,860, filed on Aug. 2, 2021.
Prior Publication US 2023/0068750 A1, Mar. 2, 2023
Int. Cl. A61K 47/69 (2017.01); A61K 9/1273 (2025.01); A61K 9/1277 (2025.01); A61K 31/704 (2006.01); A61K 47/58 (2017.01); A61K 49/00 (2006.01); C12N 15/88 (2006.01)
CPC A61K 47/6925 (2017.08) [A61K 9/1273 (2013.01); A61K 9/1277 (2013.01); A61K 31/704 (2013.01); A61K 47/58 (2017.08); A61K 47/6935 (2017.08); C12N 15/88 (2013.01); A61K 49/0084 (2013.01)] 22 Claims
 
1. A dimer molecule according to general Formula (I), comprising:

OG Complex Work Unit Chemistry
wherein:
R1 is a hydrophobic tail having at least 6 carbons;
R2 is selected from the group consisting of

OG Complex Work Unit Chemistry
a linker of the dimer of Formula (I) is a saturated carbon chain having 2 to 6 carbons or is a para-xylene linker;
and wherein:
when R2 is

OG Complex Work Unit Chemistry
anions are present to render the dimer neutral.