US 12,478,677 B2
Tunable luminescent organic salts for enhanced imaging and photodynamic therapy
Richard R. Lunt, Williamston, MI (US); Sophia Y. Lunt, Williamston, MI (US); Deanna Broadwater, Haslett, MI (US); Margaret Young, Hillsboro, OR (US); and Matthew Bates, East Lansing, MI (US)
Assigned to Board of Trustees of Michigan State University, East Lansing, MI (US)
Appl. No. 16/637,192
Filed by BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY, East Lansing, MI (US)
PCT Filed Aug. 8, 2018, PCT No. PCT/US2018/045779
§ 371(c)(1), (2) Date Feb. 6, 2020,
PCT Pub. No. WO2019/032683, PCT Pub. Date Feb. 14, 2019.
Claims priority of provisional application 62/542,350, filed on Aug. 8, 2017.
Prior Publication US 2020/0230238 A1, Jul. 23, 2020
Int. Cl. A61K 41/00 (2020.01); A61K 49/00 (2006.01)
CPC A61K 41/0057 (2013.01) [A61K 49/0032 (2013.01); A61K 49/0065 (2013.01)] 28 Claims
 
1. A method of exciting an organic salt nanoparticle in a cancer cell, the method comprising administering the organic salt nanoparticle to a subject having the cancer cell; and:
exposing the organic salt nanoparticle within the cancer cell to light having a first wavelength to induce a photodynamic effect at a concentration ranging from 5 nM to 1 mM, the organic salt nanoparticle comprising an organic salt exposed on an outermost surface, the organic salt nanoparticle comprising a photoactive ion and a counterion, the organic salt nanoparticle being free of a coating within the cancer cell and non-toxic to the cancer cell in the dark at the concentration ranging from 5 nM to 1 mM, wherein
the organic salt absorbs the light having the first wavelength and the photoactive ion becomes excited wherein the nanoparticle has a diameter of greater than or equal to 0.5 nm to less than or equal to 50 nm,
the organic salt has a lightIC50 of less than 1200 μM, and
the photoactive ion is a cationic or anionic form of a photoactive molecule selected from the group consisting of porphyrins, rhodamines, cyanines, polymethines, heptamethines, phthalocyanines, squaraines, perylenes, quinines, xanthenes, naphthalenes, coumarins, oxadiazoles, oxazines, acridines, arylmethines, tetrapyrroles, indocarbocyanines, oxacarbocyanines, thiacarbocyanines, merocyanines, porfimers, derivatives thereof, and combinations thereof.