US 12,478,667 B2
Vaccines for recurrent respiratory papillomatosis and methods of using the same
Stephanie Ramos, Santee, CA (US); Jewell Walters, Poway, CA (US); Jian Yan, Wallingford, PA (US); Anna Slager, Lansdale, PA (US); Charles Reed, Souderton, PA (US); and Kate Broderick, San Diego, CA (US)
Assigned to Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA (US)
Filed by Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA (US)
Filed on Jul. 17, 2023, as Appl. No. 18/353,421.
Application 18/353,421 is a continuation of application No. 17/320,944, filed on May 14, 2021, granted, now 11,744,885.
Claims priority of provisional application 63/024,912, filed on May 14, 2020.
Prior Publication US 2023/0414744 A1, Dec. 28, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/12 (2006.01); C07K 14/025 (2006.01); A61K 39/00 (2006.01)
CPC A61K 39/12 (2013.01) [C07K 14/025 (2013.01); A61K 2039/5254 (2013.01); A61K 2039/54 (2013.01); A61K 2039/55538 (2013.01)] 36 Claims
 
1. A nucleic acid molecule comprising a nucleic acid sequence encoding a human papillomavirus 11 (HPV11) E6 antigen, a nucleic acid sequence encoding a HPV11 E7 antigen, a nucleic acid sequence encoding a human papillomavirus 6 (HPV6) E6 antigen, and a nucleic acid sequence encoding a HPV6 E7 antigen, wherein:
the HPV11 E6 antigen comprises residues 1-149 of SEQ ID NO: 1 or an amino acid sequence having at least 99% identity to residues 1-149 of SEQ ID NO: 1,
the HPV11 E7 antigen comprises residues 179-275 of SEQ ID NO: 1 or an amino acid sequence having at least 99% identity to residues 179-275 of SEQ ID NO: 1,
the HPV6 E6 antigen comprises residues 305-453 of SEQ ID NO: 1 or an amino acid sequence having at least 99% identity to residues 305-453 of SEQ ID NO: 1, and
the HPV6 E7 antigen comprises residues 483-579 of SEQ ID NO: 1 or an amino acid sequence having at least 99% identity to residues 483-579 of SEQ ID NO: 1; and
wherein:
the nucleic acid sequence encoding a HPV11 E6 antigen comprises nucleotides 1-447 of SEQ ID NO: 2 or a nucleic acid sequence having at least 99% identity to nucleotides 1-447 of SEQ ID NO: 2,
the nucleic acid sequence encoding a HPV11 E7 antigen comprises nucleotides 535-825 of SEQ ID NO: 2 or a nucleic acid sequence having at least 99% identity to nucleotides 535-825 of SEQ ID NO: 2,
the nucleic acid sequence encoding a HPV6 E6 antigen comprises nucleotides 913-1359 of SEQ ID NO: 2 or a nucleic acid sequence having at least 99% identity to nucleotides 913-1359 of SEQ ID NO: 2,
the nucleic acid sequence encoding a HPV6 E7 antigen comprises nucleotides 1447-1737 of SEQ ID NO: 2 or a nucleic acid sequence having at least 99% identity to nucleotides 1447-1737 of SEQ ID NO: 2, or
any combination thereof.