US 12,478,632 B2
Method for ameliorating progression of renal fibrosis and treating renal fibrosis by 5-(2′,4′-difluorophenyl)-salicylanilide derivatives
Shuk-Man Ka, Taipei (TW); Hsu-shan Huang, Taipei (TW); and Ann Chen, Taipei (TW)
Assigned to NATIONAL DEFENSE MEDICAL UNIVERSITY, Taipei (TW)
Filed by National Defense Medical University, Taipei (TW)
Filed on Oct. 10, 2023, as Appl. No. 18/484,252.
Application 18/484,252 is a continuation of application No. 17/308,679, filed on May 5, 2021, abandoned.
Prior Publication US 2024/0033271 A1, Feb. 1, 2024
Int. Cl. A61K 31/609 (2006.01); A61K 31/536 (2006.01); A61P 13/12 (2006.01)
CPC A61K 31/609 (2013.01) [A61K 31/536 (2013.01); A61P 13/12 (2018.01)] 9 Claims
OG exemplary drawing
 
1. A method of ameliorating a renal fibrosis or treating a renal fibrosis in a subject in need thereof, comprising administering an effective amount of 6-(2,4-difluorophenyl)-3-(3-(trifluoromethyl)phenyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-dione to the subject, wherein the 6-(2,4-difluorophenyl)-3-(3-(trifluoromethyl)phenyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-dione attenuates renal fibrosis of the subject, and the subject suffers from renal tubulointerstitial lesions (TILs).