US 12,478,574 B2
Oral care compositions
Carl Myers, Wayne, NJ (US)
Assigned to Colgate-Palmolive Company, New York, NY (US)
Filed by Colgate-Palmolive Company, New York, NY (US)
Filed on Nov. 7, 2017, as Appl. No. 15/805,219.
Claims priority of provisional application 62/419,378, filed on Nov. 8, 2016.
Prior Publication US 2018/0125771 A1, May 10, 2018
Int. Cl. A61K 8/81 (2006.01); A61K 8/03 (2006.01); A61K 8/24 (2006.01); A61K 8/44 (2006.01); A61K 8/49 (2006.01); A61K 8/86 (2006.01); A61Q 11/00 (2006.01)
CPC A61K 8/8164 (2013.01) [A61K 8/03 (2013.01); A61K 8/24 (2013.01); A61K 8/44 (2013.01); A61K 8/4926 (2013.01); A61K 8/8147 (2013.01); A61K 8/86 (2013.01); A61Q 11/00 (2013.01); A61K 2800/48 (2013.01); A61K 2800/594 (2013.01)] 9 Claims
 
1. A mouthwash comprising an aqueous solution of
a) an acidic polymer, wherein the acidic polymer comprises a combination of
i) copolymer of methyl vinyl ether/maleic anhydride, and
ii) co-polymerized products of a mixture of acrylic acid, methacrylic acid, and 2-hydroxyethyl methacrylate phosphates of Formula 1:

OG Complex Work Unit Chemistry
wherein n is 0, 1 or 2;
and wherein the acidic polymer is present in a total amount of 1% to 5%;
b) a nonionic polymer comprising a combination of (i) polyethylene glycol having an average molecular weight of 5 kDa to 35 kDa, and (ii) poloxamer 407, in a total amount of 3 to 10%;
c) a cationic active agent, in free or orally acceptable salt form, comprising cetyl pyridinium chloride (CPC), in an amount of 0.05 to 0.1%;
d) a stabilizing amount of lysine, in free or salt form, wherein the lysine is present in an amount of about 1 to 10% by weight, relative to the total weight of the composition;
e) water in an amount of 70-95%; and
f) an orally acceptable carrier comprising a humectant, flavoring, sweetener, preservative, and dye;
wherein all ingredients are orally acceptable and wherein all amounts are by weight of the total composition;
wherein the solution comprises two distinct aqueous phases having different composition and density and comprises glutamic acid; and
wherein the addition of lysine and glutamic acid are in amounts effective to free CPC and make it more readily available for interaction with bacteria relative to control formulations that contain CPC and an acidic polymer but do not contain lysine and glutamic acid.