US 12,478,566 B2
Color stable skin benefit compositions
Anjing Lou, Seymour, CT (US); Congling Quan, Woodbridge, CT (US); William Zavoluk, Milford, CT (US); and Teanoosh Moaddel, Watertown, CT (US)
Assigned to Conopco, Inc., Hoboken, NJ (US)
Filed by Conopco, Inc., Englewood Cliffs, NJ (US)
Filed on Apr. 26, 2024, as Appl. No. 18/647,063.
Application 18/647,063 is a continuation of application No. 16/630,140, abandoned, previously published as PCT/EP2018/066640, filed on Jun. 21, 2018.
Claims priority of application No. 17180848 (EP), filed on Jul. 12, 2017.
Prior Publication US 2024/0285486 A1, Aug. 29, 2024
Int. Cl. A61K 8/06 (2006.01); A61K 8/34 (2006.01); A61K 8/67 (2006.01); A61K 8/92 (2006.01); A61Q 19/08 (2006.01); B82Y 5/00 (2011.01)
CPC A61K 8/068 (2013.01) [A61K 8/345 (2013.01); A61K 8/671 (2013.01); A61K 8/92 (2013.01); A61Q 19/08 (2013.01); A61K 2800/10 (2013.01); A61K 2800/413 (2013.01); A61K 2800/524 (2013.01); B82Y 5/00 (2013.01)] 15 Claims
 
1. A method for improving color stability of an end use composition by reducing discoloration originating from active comprising 4-ethyl resorcinol, 4-hexyl resorcinol or both, and retinyl propionate, retinol or both present in the end use composition, the method comprising the steps of:
a) preparing a water continuous nanoemulsion by mixing with homogenization at a pressure from 1,500 to 6,000 psi (a) the active; (b) water; (c) water soluble humectant (d) oil; and (e) emulsifier, wherein:
i) the active is soluble in the oil;
ii) oil as particle in the nanoemulsion has a particle size from 0.05 to less than 1.5 microns; and
iii) the nanoemulsion comprises at least 30% by weight oil;
b) combining the nanoemulsion with an emulsion chassis, the emulsion chassis being water continuous; and
c) shearing the nanoemulsion and emulsion chassis after combining to produce the end use composition; and
d) recovering the end use composition, wherein the nanoemulsion makes up from 25 to 60% by weight of the end use composition and the end use composition is water continuous.