| CPC A61B 17/1114 (2013.01) [A61B 17/0057 (2013.01); A61B 17/11 (2013.01); A61F 2/06 (2013.01); A61F 2/90 (2013.01); A61B 17/064 (2013.01); A61B 2017/0641 (2013.01); A61B 17/08 (2013.01); A61B 17/083 (2013.01); A61B 2017/1103 (2013.01); A61B 2017/1107 (2013.01); A61B 2017/1132 (2013.01); A61B 2017/1135 (2013.01); A61B 2017/1139 (2013.01); A61F 2002/077 (2013.01)] | 22 Claims |

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1. A medical device comprising:
a frame comprising an elongate member defining:
a first apposition portion comprising one or more first flange members configured to contact a first tissue surface and to provide an apposition force against said first tissue surface;
a second apposition portion comprising one or more second flange members configured to contact a second tissue surface and to provide an apposition force against said second tissue surface; and
a central portion having a first end and a second end, said central portion defining a longitudinal axis, said central portion being disposed between and interconnecting said first apposition portion and said second apposition portion, the central portion including axial adjustment members and the axial adjustment members interconnected by a single cell or by two or more cells,
wherein at least one of said one or more first flange members and at least one of said second flange members comprises a radius portion extending from the central portion and a descending portion that extends from the radius portion and longitudinally toward said central portion,
wherein at least one of said radius portions of said one or more first flange members extends longitudinally beyond said first end, and
wherein at least one of said radius portions of said one or more second flange members extends longitudinally beyond said second end.
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