US 12,478,347 B2
Non-metallic ultrasound-detectable markers
Christine U. Lee, Byron, MN (US); James F. Greenleaf, Rochester, MN (US); James L. Herrick, Rochester, MN (US); Alan L. Miller, II, Rochester, MN (US); Michael J. Yaszemski, Rochester, MN (US); James W. Jakub, Rochester, MN (US); Matthew W. Urban, Rochester, MN (US); Benjamin G. Wood, Rochester, MN (US); and Nathan J. Brinkman, Rochester, MN (US)
Assigned to Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Appl. No. 17/762,018
Filed by Mayo Foundation for Medical Education and Research, Rochester, MN (US)
PCT Filed Sep. 21, 2020, PCT No. PCT/US2020/051844
§ 371(c)(1), (2) Date Mar. 18, 2022,
PCT Pub. No. WO2021/055966, PCT Pub. Date Mar. 25, 2021.
Claims priority of provisional application 62/903,078, filed on Sep. 20, 2019.
Prior Publication US 2022/0362411 A1, Nov. 17, 2022
Int. Cl. A61B 8/08 (2006.01); A61B 8/00 (2006.01); A61B 90/00 (2016.01); A61K 49/22 (2006.01); A61N 5/10 (2006.01)
CPC A61B 8/0841 (2013.01) [A61B 8/4494 (2013.01); A61B 8/46 (2013.01); A61B 8/469 (2013.01); A61B 8/481 (2013.01); A61B 8/488 (2013.01); A61B 8/5269 (2013.01); A61B 90/39 (2016.02); A61K 49/221 (2013.01); A61K 49/223 (2013.01); A61N 5/1007 (2013.01); A61B 2090/3925 (2016.02)] 20 Claims
OG exemplary drawing
 
1. An ultrasound-detectable marker, comprising:
a body formed of a non-metallic material using an additive manufacturing process, wherein the body has formed therein a plurality of features that when imaged using Doppler ultrasound will generate a twinkling artifact, the plurality of features comprising physical deformations formed in the body by the additive manufacturing process and a surface texture formed in a surface of the body using the additive manufacturing process.