US 12,478,268 B2
Apparatus and method for non-invasively measuring blood pressure of mammal subject
John A. Rogers, Wilmette, IL (US); Shuai Xu, Bala Cynwyd, PA (US); Yinji Ma, Evanston, IL (US); Jungil Choi, Evanston, IL (US); Aurelie Hourlier-Fargette, Evanston, IL (US); and Yonggang Huang, Evanston, IL (US)
Assigned to Northwestern University, Evanston, IL (US)
Filed by NORTHWESTERN UNIVERSITY, Evanston, IL (US)
Filed on Oct. 31, 2019, as Appl. No. 16/670,161.
Claims priority of provisional application 62/753,625, filed on Oct. 31, 2018.
Claims priority of provisional application 62/753,453, filed on Oct. 31, 2018.
Claims priority of provisional application 62/753,303, filed on Oct. 31, 2018.
Prior Publication US 2020/0129077 A1, Apr. 30, 2020
Int. Cl. A61B 5/00 (2006.01); A61B 5/01 (2006.01); A61B 5/02 (2006.01); A61B 5/021 (2006.01); A61B 5/022 (2006.01); A61B 5/024 (2006.01); A61B 5/026 (2006.01); A61B 5/08 (2006.01); A61B 5/11 (2006.01); A61B 5/145 (2006.01); A61B 5/1455 (2006.01); A61B 5/28 (2021.01); H04W 4/80 (2018.01)
CPC A61B 5/022 (2013.01) [A61B 5/0004 (2013.01); A61B 5/0006 (2013.01); A61B 5/0022 (2013.01); A61B 5/0024 (2013.01); A61B 5/0051 (2013.01); A61B 5/01 (2013.01); A61B 5/02028 (2013.01); A61B 5/02108 (2013.01); A61B 5/02405 (2013.01); A61B 5/02416 (2013.01); A61B 5/02427 (2013.01); A61B 5/0261 (2013.01); A61B 5/0816 (2013.01); A61B 5/11 (2013.01); A61B 5/14542 (2013.01); A61B 5/14552 (2013.01); A61B 5/28 (2021.01); A61B 5/4205 (2013.01); A61B 5/6801 (2013.01); A61B 5/6823 (2013.01); A61B 5/6825 (2013.01); A61B 5/6828 (2013.01); A61B 5/683 (2013.01); A61B 5/6833 (2013.01); A61B 5/7207 (2013.01); A61B 5/7225 (2013.01); A61B 5/7285 (2013.01); A61B 5/7405 (2013.01); A61B 5/742 (2013.01); A61B 5/746 (2013.01); A61B 5/747 (2013.01); H04W 4/80 (2018.02); A61B 2503/045 (2013.01); A61B 2503/40 (2013.01); A61B 2560/0214 (2013.01); A61B 2562/0204 (2013.01); A61B 2562/0219 (2013.01); A61B 2562/0271 (2013.01); A61B 2562/162 (2013.01); A61B 2562/164 (2013.01); A61B 2562/227 (2013.01)] 42 Claims
OG exemplary drawing
 
1. An apparatus for non-invasively measuring a blood pressure of a mammal subject, comprising:
a first sensor system and a second sensor system that are time-synchronized to each other and spatially separated by a pulse arrival distance L, wherein the first sensor system is attached to a first position of the mammal subject for detecting a first signal, the second sensor system attached to a second position of the mammal subject for detecting a second signal, the second position is more distal or proximal to a heart of the mammal subject than the first position, and the pulse arrival distance L is defined by the first and second positions, wherein each of the first sensor system and the second sensor system comprises:
a plurality of electronic components, and a plurality of flexible and stretchable interconnects electrically connected to different electronic components, wherein the plurality of electronic components comprise a sensor member for measuring the first signal or the second signal of the mammal subject;
an elastomeric encapsulation layer at least partially surrounding the plurality of electronic components and the plurality of flexible and stretchable interconnects to form a tissue-facing surface operably attached to the mammal subject and an environment-facing surface; and
a microfluidic chamber formed between the tissue-facing surface and the plurality of electronic components in the elastomeric encapsulation layer;
wherein the sensor member of the first sensor system includes at least one electrode, and the microfluidic chamber of the first sensor system has at least one through openings defined therethrough such that during use the at least one electrode is directly in epidermal contact with a skin surface of the mammal subject through the at least one opening for detecting the first signal; and
a microcontroller unit (MCU) adapted in wireless communication with the first sensor system and the second sensor system, and configured to:
receive output signals of the first sensor system and the second sensor system;
process the output signals to determine a pulse arrival time (PAT) as a time delay Δt between detection of the first signal and detection of the second signal;
determine a pulse wave velocity (PWV) based on the PAT and the pulse arrival distance L, wherein

OG Complex Work Unit Math
and
determine the blood pressure P of the mammal subject from the PWV, wherein P is a parabolic function of the PWV.