US 12,148,606 B2
Methods for sampling into an atmospheric pressure inlet mass spectrometer
Theresa Evans-Nguyen, Brandon, FL (US); Linxia Song, Temple Terrace, FL (US); and Yi You, Shandong (CN)
Assigned to University of South Florida, Tampa, FL (US)
Appl. No. 17/768,089
Filed by University of South Florida, Tampa, FL (US)
PCT Filed Oct. 13, 2020, PCT No. PCT/US2020/055312
§ 371(c)(1), (2) Date Apr. 11, 2022,
PCT Pub. No. WO2021/076464, PCT Pub. Date Apr. 22, 2021.
Claims priority of provisional application 62/915,349, filed on Oct. 15, 2019.
Prior Publication US 2024/0096610 A1, Mar. 21, 2024
Int. Cl. H01J 49/00 (2006.01); H01J 49/04 (2006.01); H01J 49/24 (2006.01)
CPC H01J 49/0095 (2013.01) [H01J 49/0454 (2013.01); H01J 49/24 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An analytical system for analyzing an analyte, the analytical system comprising:
a mass spectrometer having an input;
an ultrasonic nebulizer chip operatively coupled to the mass spectrometer, such that when the ultrasonic nebulizer chip nebulizes the analyte to provide a nebulized analyte, at least some of the nebulized analyte enters the input of the mass spectrometer;
wherein the ultrasonic nebulizer chip comprises a continuous-mode driver;
wherein the ultrasonic nebulizer chip is operatively coupled with an atmospheric pressure chemical ionization device;
wherein the atmospheric pressure chemical ionization device has an ionization efficiency greater than an ionization efficiency produced by the atmospheric pressure chemical ionization device alone.