US 12,148,602 B2
Adaptive intrinsic lock mass correction
Keith George Richardson, High Peak (GB); Martin Raymond Green, Bowdon (GB); John Brian Hoyes, Stockport (GB); Richard Denny, Staffordshire (GB); Peter Nixon, Cheshire (GB); and Richard Chapman, Westborough, MA (US)
Assigned to Micromass UK Limited, Wilmslow (GB)
Appl. No. 17/638,640
Filed by Micromass UK Limited, Wilmslow (GB)
PCT Filed Aug. 28, 2020, PCT No. PCT/GB2020/052069
§ 371(c)(1), (2) Date Feb. 25, 2022,
PCT Pub. No. WO2021/038242, PCT Pub. Date Mar. 4, 2021.
Claims priority of provisional application 62/894,298, filed on Aug. 30, 2019.
Claims priority of application No. 1912494 (GB), filed on Aug. 30, 2019.
Prior Publication US 2022/0301838 A1, Sep. 22, 2022
Int. Cl. H01J 49/00 (2006.01)
CPC H01J 49/0009 (2013.01) [H01J 49/0036 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A method of mass spectrometry comprising:
mass analysing a sample;
introducing an external or extrinsic lock mass sample or calibrant at a first time t1,
making a first external calibration measurement at or in relation to the first time t1;
recognising one or more intermediate components which are first present or first observed after the first time t1; and
calculating or determining a correction factor based upon at least some of the one or more intermediate components.