US 12,148,511 B2
System and method for conducting virtual crossover studies in clinical diagnostic processes
John Yundt-Pacheco, Fairview, TX (US); and Curtis Parvin, Garland, TX (US)
Assigned to Bio-Rad Laboratories, Inc., Hercules, CA (US)
Filed by Bio-Rad Laboratories, Inc., Hercules, CA (US)
Filed on Jun. 4, 2021, as Appl. No. 17/338,937.
Application 17/338,937 is a continuation of application No. PCT/US2020/066563, filed on Dec. 22, 2020.
Prior Publication US 2022/0199206 A1, Jun. 23, 2022
Int. Cl. G16H 10/40 (2018.01)
CPC G16H 10/40 (2018.01) 15 Claims
OG exemplary drawing
 
1. A clinical diagnostic analyzer for conducting virtual crossover studies, comprising:
a processor;
measurement hardware in communication with the processor and configured to measure properties of an analyte;
a memory device having stored thereon executable instructions that, when executed by the processor, cause the clinical diagnostic analyzer to perform operations comprising:
acquiring data for an old lot of quality control material;
acquiring data for a new lot of quality control material from a peer group of clinical diagnostic analyzers;
calculating a predicted mean and standard deviation for the new lot of quality control material based on the acquired data for the old lot of quality control material and the acquired peer group data for the new lot of quality control material;
storing in the memory device the calculated mean and standard deviation for use in in testing;
running a target number of analyses on a specimen from the new lot of quality control material;
updating the calculated predicted mean and standard deviation for the new lot of quality control material based on data acquired by the analyses, wherein updating the calculated predicted mean and standard deviation comprises weighting the effect of the data acquired by the analyses in the calculation based on the number of analyses completed;
controlling and commanding an automated loading mechanism to load a patient specimen for testing; and
testing the patient specimen using the updated mean and standard deviation.