US 12,148,154 B2
Systems and methods for detection and staging of pulmonary fibrosis from image-acquired data
Andrew Dennis Smith, Hoover, AL (US)
Assigned to THE UAB RESEARCH FOUNDATION, Birmingham, AL (US)
Filed by The UAB Research Foundation, Birmingham, AL (US)
Filed on Mar. 11, 2022, as Appl. No. 17/692,982.
Application 17/692,982 is a division of application No. 17/223,178, filed on Apr. 6, 2021, granted, now 11,295,445.
Application 17/223,178 is a continuation of application No. PCT/US2020/056679, filed on Oct. 21, 2020.
Claims priority of provisional application 62/924,144, filed on Oct. 21, 2019.
Prior Publication US 2022/0198664 A1, Jun. 23, 2022
Int. Cl. G06T 7/00 (2017.01); G06T 7/13 (2017.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01)
CPC G06T 7/0012 (2013.01) [G06T 7/13 (2017.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01); G06T 2207/10081 (2013.01); G06T 2207/30064 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A computer-implemented method for ascertaining pulmonary fibrosis disease progression or treatment response; comprising:
obtaining a first set of computed tomography (CT) images of a lung, the first set of CT images of the lung being associated with a first timepoint;
determining a first Pulmonary Surface Index (PSI) score for the lung, wherein determining the first PSI score for the lung includes:
detecting a first actual lung boundary of the lung within the first set of CT images, the first actual lung boundary extending about at least a first perimeter of the lung;
determining a first approximated lung boundary within the first set of CT images, the first approximated lung boundary extending about at least the first perimeter of the lung, wherein the first approximated lung boundary comprises a representation of a smooth lung boundary for the first perimeter of the lung; and
determining the first PSI score for the lung using inputs based on the first actual lung boundary and the first approximated lung boundary;
obtaining a second set of CT images of the lung, the second set of CT images of the lung being associated with a second timepoint, the second timepoint being different than the first timepoint;
determining a second PSI score for the lung, wherein determining the second PSI score for the lung includes:
detecting a second actual lung boundary of the lung within the second set of CT images, the second actual lung boundary extending about at least a second perimeter of the lung;
determining a second approximated lung boundary within the second set of CT images, the second approximated lung boundary extending about at least the second perimeter of the lung, wherein the second approximated lung boundary comprises a representation of a smooth lung boundary for the second perimeter of the lung; and
determining the second PSI score for the lung using inputs based on the second actual lung boundary and the second approximated lung boundary; and
assessing pulmonary fibrosis treatment response or disease progression for the lung based on the first PSI score and the second PSI score.