US 12,146,878 B2
Method, apparatus and system for detecting and determining comprised reagent pads by quantifying color changes induced by exposure to a hostile environment
Bernard Burg, Menlo Park, CA (US); Martin Zizi, Enines (BE); Walter De Brouwer, Los Altos, CA (US); Jaime Tenedorio, Portola Valley, CA (US); Babak Aghazadeh, Fremont, CA (US); Jie Cui, Sunnyvale, CA (US); and Sheena Menezes, Los Gatos, CA (US)
Assigned to HEALTHY.IO LTD., Tel Aviv (IL)
Filed by HEALTHY.IO LTD., Tel Aviv-Jaffa (IL)
Filed on Aug. 1, 2023, as Appl. No. 18/363,218.
Application 18/363,218 is a continuation of application No. 17/206,399, filed on Mar. 19, 2021, granted, now 11,754,564.
Application 17/206,399 is a continuation of application No. 16/246,406, filed on Jan. 11, 2019, granted, now 10,983,065, issued on Apr. 20, 2021.
Application 16/246,406 is a continuation of application No. 15/289,961, filed on Oct. 10, 2016, abandoned.
Application 15/289,961 is a continuation in part of application No. 14/639,509, filed on Mar. 5, 2015, granted, now 9,528,941, issued on Dec. 27, 2016.
Application 14/639,509 is a continuation in part of application No. 14/419,939, granted, now 9,311,520, issued on Apr. 12, 2016, previously published as PCT/US2013/035397, filed on Apr. 5, 2013.
Claims priority of provisional application 61/948,536, filed on Mar. 5, 2014.
Claims priority of provisional application 61/680,842, filed on Aug. 8, 2012.
Prior Publication US 2023/0384305 A1, Nov. 30, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/543 (2006.01); G01N 21/78 (2006.01); G01N 21/79 (2006.01); G01N 21/80 (2006.01); G01N 21/81 (2006.01); G01N 21/84 (2006.01); G01N 33/52 (2006.01); G06T 7/90 (2017.01)
CPC G01N 33/54388 (2021.08) [G01N 21/78 (2013.01); G01N 21/79 (2013.01); G01N 21/80 (2013.01); G01N 21/81 (2013.01); G01N 21/8483 (2013.01); G01N 33/52 (2013.01); G06T 7/90 (2017.01); G01N 2021/8488 (2013.01); G01N 2021/8494 (2013.01)] 14 Claims
OG exemplary drawing
 
8. A method for analyzing a digital image of an at-home diagnostic instrument, the method comprising:
capturing a digital image of at least a portion of an at-home diagnostic instrument with at least one camera sensor, the at-home diagnostic instrument including at least one color reference with a plurality of reference samples of different colors, at least one test medium having a reagent that changes color in a presence of particular analytes in a biological sample, and at least one contamination detection medium having a reagent that changes color in response to being exposed to a hostile environment;
identifying at least one reference sample of the plurality of reference samples associated with the at least one contamination detection medium;
determining a dominant camera-captured color of the at least one reference sample and a dominant camera-captured color of the at least one contamination detection medium;
color correcting the dominant camera-captured color of the at least one contamination detection medium to determine a corrected contamination detection medium color in response to a correction factor derived at least in part from the dominant camera-captured color of the at least one reference sample; and
comparing the corrected contamination detection medium color to a predetermined contamination detection medium color to determine if the at-home diagnostic instrument has been exposed to a hostile environment and compromised.