US 12,146,006 B2
Synthesis of echinocandin antifungal agent
David Hughes, San Diego, CA (US); Martin Patrick Hughes, Spokane, WA (US); Balasingam Radhakrishnan, Chapel Hill, NC (US); Robert Michael Hughes, San Diego, CA (US); Yannick Borguet, Waringstown (GB); and Steven McIntyre, Moira (GB)
Assigned to Napp Pharmaceutical Group Limited, Cambridge (GB)
Filed by Napp Pharmaceutical Group Limited, Cambridge (GB)
Filed on Dec. 8, 2022, as Appl. No. 18/077,902.
Application 18/077,902 is a continuation of application No. 17/252,579, granted, now 11,524,980, previously published as PCT/US2019/037176, filed on Jun. 14, 2019.
Claims priority of provisional application 62/685,634, filed on Jun. 15, 2018.
Prior Publication US 2023/0365629 A1, Nov. 16, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 7/64 (2006.01)
CPC C07K 7/64 (2013.01) 5 Claims
 
1. A method of synthesizing compound 1:

OG Complex Work Unit Chemistry
said method comprising hydrolyzing a compound of formula (IIa):

OG Complex Work Unit Chemistry
wherein X− is an anion, to form compound 1, or a salt or neutral form thereof.