US 12,146,005 B2
Compositions and methods for treatment of fungal infections
Michael E. Selsted, Pasadena, CA (US); Dat Q. Tran, Alhambra, CA (US); Justin B. Schaal, Orange, CA (US); and Virginia Basso, Covina, CA (US)
Assigned to University of Southern California, Los Angeles, CA (US)
Filed by THE UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA (US)
Filed on Jul. 20, 2022, as Appl. No. 17/869,284.
Application 17/869,284 is a division of application No. 16/913,699, filed on Jun. 26, 2020, granted, now 11,427,617.
Claims priority of provisional application 62/867,000, filed on Jun. 26, 2019.
Prior Publication US 2023/0072433 A1, Mar. 9, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/00 (2006.01); A61P 31/00 (2006.01); C07K 7/08 (2006.01); C07K 7/64 (2006.01)
CPC C07K 7/64 (2013.01) [A61P 31/00 (2018.01); A61K 38/00 (2013.01)] 14 Claims
 
1. A cyclic peptide consisting of 14 amino acids and having the following structure:

OG Complex Work Unit Chemistry
wherein AA1 is a first amino acid, AA2 is a second amino acid, AA3 and AA12 are cysteines joined by a disulfide bond, AA5 and AA10 are cysteines joined by a disulfide bond, AA4 is serine or a first hydrophobic amino acid, AA11 is serine or a second hydrophobic amino acid, AA6 is arginine, AA7 is arginine, AA8 is arginine, AA9 is a third amino acid, AA13 is a fourth amino acid, AA14 is a fifth amino acid, wherein the cyclic peptide comprises five arginine residues that provide a positively charged content of at least about 36% at physiological pH, and wherein the cyclic peptide is not MTD1280 (SEQ ID NO: 6).