US 12,145,984 B2
Methods for preventing ischemia reperfusion injury in an organ with antibody antagonists of IL-33
André Herbelin, Poitiers (FR); Jean-Marc Gombert, Poitiers (FR); Maroua Ferhat, Salt Lake City, UT (US); Antoine Thierry, Poitiers (FR); and Jean-Philippe Girard, Toulouse (FR)
Assigned to INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Paris (FR); CENTRE HOSPITALIER UNIVERSITAIRE DE POITIERS, Poiters (FR); UNIVERSITE DE POITIERS, Poiters (FR); and CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR)
Appl. No. 16/964,785
Filed by INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), Paris (FR); UNIVERSITÉ DE POITIERS, Poitiers (FR); CENTRE HOSPITALIER UNIVERSITAIRE DE POITIERS, Poitiers (FR); and CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Paris (FR)
PCT Filed Jan. 24, 2019, PCT No. PCT/EP2019/051738
§ 371(c)(1), (2) Date Jul. 24, 2020,
PCT Pub. No. WO2019/145413, PCT Pub. Date Aug. 1, 2019.
Claims priority of application No. 18305054 (EP), filed on Jan. 24, 2018.
Prior Publication US 2021/0054064 A1, Feb. 25, 2021
Int. Cl. A61K 39/395 (2006.01); A61K 38/17 (2006.01); A61P 13/12 (2006.01); C07K 16/24 (2006.01); C12N 15/113 (2010.01); A61K 39/00 (2006.01); A61P 9/10 (2006.01); C07K 14/54 (2006.01); C07K 16/28 (2006.01)
CPC C07K 16/244 (2013.01) [A61K 38/1793 (2013.01); A61K 39/3955 (2013.01); A61P 13/12 (2018.01); C12N 15/1136 (2013.01); A61K 2039/505 (2013.01); A61P 9/10 (2018.01); C07K 14/54 (2013.01); C07K 16/2866 (2013.01); C07K 2317/76 (2013.01); C07K 2319/30 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01)] 7 Claims
 
1. A method of preventing, reducing the severity of, or reducing the risk of ischemia reperfusion injury (IRI) caused by reperfusion of an organ or tissue comprising
administering to the organ or tissue a therapeutically effective amount of an interleukin-33 (IL-33) antagonist, wherein:
the IL-33 antagonist is an antibody having binding affinity for IL-33,
the step of administering occurs before and/or during the reperfusion of the organ or tissue,
the IRI includes one or both of severe renal insufficiency and acute tubular necrosis.