US 12,145,932 B2
Method of manufacturing a solid form of a BET bromodomain inhibitor
Feng Wen, Shanghai (CN); Jiahui Chen, Shanghai (CN); Xianghui Wen, Shanghai (CN); Mark T. Edgar, Rancho Santa Fe, CA (US); and Henrik C. Hansen, Calgary (CA)
Assigned to ZENITH EPIGENETICS LTD., Calgary (CA)
Appl. No. 17/275,465
Filed by ZENITH EPIGENETICS LTD., Calgary (CA)
PCT Filed Sep. 13, 2019, PCT No. PCT/IB2019/001011
§ 371(c)(1), (2) Date Mar. 11, 2021,
PCT Pub. No. WO2020/053657, PCT Pub. Date Mar. 19, 2020.
Claims priority of provisional application 62/730,849, filed on Sep. 13, 2018.
Prior Publication US 2022/0048905 A1, Feb. 17, 2022
Int. Cl. C07D 471/04 (2006.01); B01J 23/44 (2006.01)
CPC C07D 471/04 (2013.01) [B01J 23/44 (2013.01); C07B 2200/13 (2013.01)] 21 Claims
 
1. A process of preparing crystalline Compound I, Form VII:

OG Complex Work Unit Chemistry
comprising precipitating Compound I, Form VII from a solution comprising Compound I and ethanol, t-butylmethylether (MTBE), or a mixture thereof.