US 12,145,915 B1
(E)-2-(3-cyano-4-isobutoxyphenyl)-n′-(substituted benzylidene)-4-methylthiazole-5-carbohydrazides as anti-tubercular agents
Katharigatta N. Venugopala, Al-Ahsa (SA); Pran Kishore Deb, Ranchi (IN); Melendran Pillay, Durban (ZA); Nefisath P, Ujire (IN); Mohamed A. Morsy, Al-Ahsa (SA); Shashiprabha S, Ujire (IN); Jagadeesh Prasad Dasappa, Mangalagangothri (IN); Rashmi Venugopala, Natal (CA); and Osama I. Alwassil, Al-Ahsa (SA)
Assigned to KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed by KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed on Dec. 22, 2023, as Appl. No. 18/394,610.
Application 18/394,610 is a division of application No. 18/377,533, filed on Oct. 6, 2023.
Int. Cl. C07D 277/30 (2006.01); A61P 31/06 (2006.01); C07D 417/12 (2006.01)
CPC C07D 277/30 (2013.01) [A61P 31/06 (2018.01); C07D 417/12 (2013.01)] 13 Claims
 
1. A method of treating tuberculosis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound having the formula I:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
R is selected from the group consisting of an optionally substituted phenyl and an optionally substituted furanyl.